The debranching enzyme Dbr1 regulates lariat turnover and intron splicing.
AQR
Dbr1
RNA processing
RNA splicing
intron lariats
lariat-seq
spliceosome
Journal
Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035
Informations de publication
Date de publication:
13 Jun 2023
13 Jun 2023
Historique:
pubmed:
3
7
2023
medline:
3
7
2023
entrez:
3
7
2023
Statut:
epublish
Résumé
The majority of genic transcription is intronic. Introns are removed by splicing as branched lariat RNAs which require rapid recycling. The branch site is recognized during splicing catalysis and later debranched by Dbr1 in the rate-limiting step of lariat turnover. Through generation of the first viable
Identifiants
pubmed: 37398028
doi: 10.21203/rs.3.rs-2931976/v1
pmc: PMC10312976
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM105681
Pays : United States
Organisme : NCI NIH HHS
ID : F31 CA254143
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA193318
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA092584
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA091842
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM127472
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227001
Pays : United States
Déclaration de conflit d'intérêts
DECLARATION OF INTERESTS The authors declare no competing interests. We disclose W.G.F. as the founder of Walah Scientific and member of the scientific advisory board for Remix Therapeutics.