QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration.
GWAS
aging
eQTL
eQTM
epigenome
gene expression
mQTL
neurodegeneration
retina
Journal
Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035
Informations de publication
Date de publication:
16 Jun 2023
16 Jun 2023
Historique:
pubmed:
3
7
2023
medline:
3
7
2023
entrez:
3
7
2023
Statut:
epublish
Résumé
DNA methylation (DNAm) provides a crucial epigenetic mark linking genetic variations to environmental influence. We analyzed array-based DNAm profiles of 160 human retinas with co-measured RNA-seq and > 8 million genetic variants, uncovering sites of genetic regulation in
Identifiants
pubmed: 37398472
doi: 10.21203/rs.3.rs-3011096/v1
pmc: PMC10312909
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NEI NIH HHS
ID : P30 EY014104
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY031424
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA EY000450
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA EY000546
Pays : United States
Commentaires et corrections
Type : UpdateIn
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.