A lipid toolbox of sugar alcohol fatty acid monoesters for single-component lipid nanoparticles with temperature-controlled release.

This study aimed to prepare single-component LNPs with sugar alcohol fatty acid monoesters for temperature-controlled release. In total, 20 kinds of lipids with a series of sugar alcohol head groups (ethylene glycol, glycerol, erythritol, xylitol and sorbitol) and fatty acyl tails (12:0, 14:0, 16:0 and 18:0) were synthesised via lipase-catalysed esterification. Their physicochemical properties and upper/lower critical solution temperature (LCST/USCT) were analysed. Two groups of mixed lipids, 78 % ethylene glycol lauric acid monoester + 22 % sorbitol stearic acid monoester (LNP-1) and 90 % ethylene glycol lauric acid monoester + 10 % xylitol myristic acid monoester (LNP-2), had LCST/USCT of approximately 37 °C, which formed empty LNPs using the emulsification-diffusion method. These two mixed lipids were prepared for LNPs loaded with curcumin, showing high encapsulation (>90 %), mean particle sizes of approximately 250 nm and low polydispersity index (≤0.2). These lipids have the potential for tailor-made LNPs achieving thermo-responsivity in delivering bioactive agents and drugs.

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.