Prospect of targeting lysine methyltransferase NSD3 for tumor therapy.

Lysine Humans Neoplasms / drug therapy
Anticancer Cancer Epigenetic H3K36 NSD3 SET domain

Journal

Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422

Informations de publication

Date de publication:
08 2023
Historique:
received: 21 05 2023
revised: 16 06 2023
accepted: 23 06 2023
medline: 21 8 2023
pubmed: 4 7 2023
entrez: 3 7 2023
Statut: ppublish

Résumé

Nuclear receptor binding SET domain protein 3 (NSD3) has recently been recognized as a new epigenetic target in the fight against cancer. NSD3, which is amplified, overexpressed or mutated in a variety of tumors, promotes tumor development by regulating the cell cycle, apoptosis, DNA repair and EMT. Therefore, the inhibition, silencing or knockdown of NSD3 are highly promising antitumor strategies. This paper summarizes the structure and biological functions of NSD3 with an emphasis on its carcinogenic or cancer-promoting activity. The development of NSD3-specific inhibitors or degraders is also discussed and reviewed in this paper.

Identifiants

DOI: 10.1016/j.phrs.2023.106839 PMID: 37400043
pubmed: 37400043
pii: S1043-6618(23)00195-0
doi: 10.1016/j.phrs.2023.106839
pii:
doi:

Substances chimiques

Lysine K3Z4F929H6
NSD3 protein, human EC 2.1.1.43

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

106839

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Dan Li (D)

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Tiantian Tian (T)

Center for Biological Science and Technology, Beijing Normal University, Zhuhai, Guangdong Province, 519087, China.

Chung-Nga Ko (CN)

C-MER Dennis Lam and Partners Eye Center, Hong Kong International Eye Care Group, Hong Kong, China. Electronic address: chungngako@gmail.com.

Chao Yang (C)

National Engineering Research Center For Marine Aquaculture, Institute of Innovation & Application, Zhejiang Ocean University, Zhoushan, Zhejiang Province 316022, China. Electronic address: yc52028@hotmail.com.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Lysine › Prospect of targeting lysine methyltransferase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prospect of targeting lysine methyltransferase...
questionsmedicales.fr › Tumeurs › Prospect of targeting lysine methyltransferase...