Oncogenic K-Ras suppresses global miRNA function.

Animals Mice Carcinogenesis / genetics Cell Transformation, Neoplastic / genetics Genes, ras MicroRNAs / genetics Neoplasms / genetics Proteomics
Ago2 CLIP-seq K-Ras casein kinase colon colorectal cancer miRNA

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
20 07 2023
Historique:
received: 02 11 2022
revised: 05 05 2023
accepted: 05 06 2023
pmc-release: 20 07 2024
medline: 27 7 2023
pubmed: 5 7 2023
entrez: 4 7 2023
Statut: ppublish

Résumé

K-Ras frequently acquires gain-of-function mutations (K-Ras

Identifiants

DOI: 10.1016/j.molcel.2023.06.008 PMID: 37402366 PMC: PMC10527862
pubmed: 37402366
pii: S1097-2765(23)00429-X
doi: 10.1016/j.molcel.2023.06.008
pmc: PMC10527862
mid: NIHMS1910027
pii:
doi:

Substances chimiques

MicroRNAs 0
Hras protein, mouse EC 3.6.5.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2509-2523.e13

Subventions

Organisme : NINDS NIH HHS
ID : P30 NS072030
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA178017
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA232372
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA247198
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA236733
Pays : United States
Organisme : Cancer Research UK
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA245507
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103831
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA149707
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests K.M.H. is married to a member of Molecular Cell’s Advisory Board.

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Auteurs

Bing Shui (B)

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02215, USA; Program in Biological and Biomedical Sciences, Division of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Tyler S Beyett (TS)

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Zhengyi Chen (Z)

Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Cell and Developmental Biology, Chemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Xiaoyi Li (X)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Gaspare La Rocca (G)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

William M Gazlay (WM)

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Chemistry, University of Massachusetts Boston, Boston, MA 02125, USA.

Michael J Eck (MJ)

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Ken S Lau (KS)

Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Cell and Developmental Biology, Chemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Andrea Ventura (A)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Kevin M Haigis (KM)

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02215, USA; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: kevin_haigis@dfci.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Oncogenic K-Ras suppresses global miRNA function.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Oncogenic K-Ras suppresses global miRNA function.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Oncogenic K-Ras suppresses global miRNA function.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › Oncogenic K-Ras suppresses global miRNA function.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Oncogènes › Proto-oncogènes › Gènes ras › Oncogenic K-Ras suppresses global miRNA function.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Oncogenic K-Ras suppresses global miRNA function.
questionsmedicales.fr › Tumeurs › Oncogenic K-Ras suppresses global miRNA function.
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Oncogenic K-Ras suppresses global miRNA function.