Heterologous protein production in filamentous fungi.
Filamentous fungi
Fungal cell factories
Gene regulation
Heterologous protein production
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
22
03
2023
accepted:
21
06
2023
revised:
16
06
2023
medline:
31
7
2023
pubmed:
5
7
2023
entrez:
5
7
2023
Statut:
ppublish
Résumé
Filamentous fungi are able to produce a wide range of valuable proteins and enzymes for many industrial applications. Recent advances in fungal genomics and experimental technologies are rapidly changing the approaches for the development and use of filamentous fungi as hosts for the production of both homologous and heterologous proteins. In this review, we highlight the benefits and challenges of using filamentous fungi for the production of heterologous proteins. We review various techniques commonly employed to improve the heterologous protein production in filamentous fungi, such as strong and inducible promoters, codon optimization, more efficient signal peptides for secretion, carrier proteins, engineering of glycosylation sites, regulation of the unfolded protein response and endoplasmic reticulum associated protein degradation, optimization of the intracellular transport process, regulation of unconventional protein secretion, and construction of protease-deficient strains. KEY POINTS: • This review updates the knowledge on heterologous protein production in filamentous fungi. • Several fungal cell factories and potential candidates are discussed. • Insights into improving heterologous gene expression are given.
Identifiants
pubmed: 37405433
doi: 10.1007/s00253-023-12660-8
pii: 10.1007/s00253-023-12660-8
pmc: PMC10386965
doi:
Substances chimiques
Carrier Proteins
0
Protein Sorting Signals
0
Codon
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5019-5033Subventions
Organisme : China Scholarship Council
ID : 202107720032
Informations de copyright
© 2023. The Author(s).
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