Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease.

Humans Alzheimer Disease / metabolism Proteomics Brain / metabolism Immunity, Innate Heterozygote Biomarkers / metabolism tau Proteins / metabolism Amyloid beta-Peptides / metabolism

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
05 07 2023
Historique:
medline: 7 7 2023
pubmed: 5 7 2023
entrez: 5 7 2023
Statut: ppublish

Résumé

Proteomic studies for Alzheimer's disease (AD) are instrumental in identifying AD pathways but often focus on single tissues and sporadic AD cases. Here, we present a proteomic study analyzing 1305 proteins in brain tissue, cerebrospinal fluid (CSF), and plasma from patients with sporadic AD,

Identifiants

DOI: 10.1126/scitranslmed.abq5923 PMID: 37406134
pubmed: 37406134
doi: 10.1126/scitranslmed.abq5923
doi:

Substances chimiques

Biomarkers 0
tau Proteins 0
Amyloid beta-Peptides 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabq5923

Subventions

Organisme : NIA NIH HHS
ID : P30 AG066444
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003991
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058501
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG074007
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG053303
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG032438
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG026276
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG044546
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG058922
Pays : United States

Auteurs

Yun Ju Sung (YJ)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63108, USA.
ORCID: 0000-0002-8021-4070

Chengran Yang (C)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
ORCID: 0000-0003-4577-5590

Joanne Norton (J)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA.

Matt Johnson (M)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA.

Anne Fagan (A)

Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA.

Randall J Bateman (RJ)

Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA.
ORCID: 0000-0002-7729-1702

Richard J Perrin (RJ)

Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA.
ORCID: 0000-0002-3443-7716

John C Morris (JC)

Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA.
ORCID: 0000-0001-9820-5618

Martin R Farlow (MR)

Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
ORCID: 0000-0001-7897-5471

Jasmeer P Chhatwal (JP)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-7792-1698

Peter R Schofield (PR)

Neuroscience Research Australia, Randwick, NSW 2031, Australia.
School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
ORCID: 0000-0003-2967-9662

Helena Chui (H)

Department of Neurology, University of Southern California, Los Angeles, CA 90089, USA.

Fengxian Wang (F)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
ORCID: 0000-0002-7677-5406

Brenna Novotny (B)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.
ORCID: 0000-0003-4732-1736

Abdallah Eteleeb (A)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.
ORCID: 0000-0001-9045-250X

Celeste Karch (C)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
ORCID: 0000-0002-6854-5547

Suzanne E Schindler (SE)

Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA.
ORCID: 0000-0002-1680-1465

Herve Rhinn (H)

Leal Therapeutics, 17 Briden St., Office 329, Worcester, MA 01605, USA.

Erik C B Johnson (ECB)

Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA.
ORCID: 0000-0002-0604-2944

Hamilton Se-Hwee Oh (HS)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.
ORCID: 0000-0001-8192-7593

Jarod Evert Rutledge (JE)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.
ORCID: 0000-0001-7790-2801

Eric B Dammer (EB)

Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA.
ORCID: 0000-0003-2947-7606

Nicholas T Seyfried (NT)

Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA.
Department of Biochemistry, Emory School of Medicine, Atlanta, GA 30329, USA.
ORCID: 0000-0002-8694-9211

Tony Wyss-Coray (T)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.
ORCID: 0000-0001-5893-0831

Oscar Harari (O)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.
ORCID: 0000-0002-2635-6975

Carlos Cruchaga (C)

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63108, USA.
NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
ORCID: 0000-0002-0276-2899

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Proteomics of brain, CSF, and plasma...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Proteomics of brain, CSF, and plasma...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Proteomics of brain, CSF, and plasma...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Proteomics of brain, CSF, and plasma...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Proteomics of brain, CSF, and plasma...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Hétérozygote › Proteomics of brain, CSF, and plasma...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Proteomics of brain, CSF, and plasma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Proteomics of brain, CSF, and plasma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Proteomics of brain, CSF, and plasma...