Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson's disease.

Humans Parkinson Disease / metabolism Transcriptome Brain / metabolism Corpus Striatum / metabolism Putamen

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
05 07 2023
Historique:
received: 21 03 2023
accepted: 23 06 2023
medline: 7 7 2023
pubmed: 6 7 2023
entrez: 5 7 2023
Statut: epublish

Résumé

The ability to use blood to predict the outcomes of Parkinson's disease, including disease progression and cognitive and motor complications, would be of significant clinical value. We undertook bulk RNA sequencing from the caudate and putamen of postmortem Parkinson's disease (n = 35) and control (n = 40) striatum, and compared molecular profiles with clinical features and bulk RNA sequencing data obtained from antemortem peripheral blood. Cognitive and motor complications of Parkinson's disease were associated with molecular changes in the caudate (stress response) and putamen (endothelial pathways) respectively. Later and earlier-onset Parkinson's disease were molecularly distinct, and disease duration was associated with changes in caudate (oligodendrocyte development) and putamen (cellular senescence), respectively. Transcriptome patterns in the postmortem Parkinson's disease brain were also evident in antemortem peripheral blood, and correlated with clinical features of the disease. Together, these findings identify molecular signatures in Parkinson's disease patients' brain and blood of potential pathophysiologic and prognostic importance.

Identifiants

DOI: 10.1038/s41467-023-39652-6 PMID: 37407548 PMC: PMC10322907
pubmed: 37407548
doi: 10.1038/s41467-023-39652-6
pii: 10.1038/s41467-023-39652-6
pmc: PMC10322907
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3956

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS081706
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS117583
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107442
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG064596
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS111176
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS097404
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Krithi Irmady (K)

Laboratory of Molecular Neuro-oncology, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA. kirmady@rockefeller.edu.
ORCID: 0000-0003-2034-1809

Caryn R Hale (CR)

Laboratory of Molecular Neuro-oncology, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.

Rizwana Qadri (R)

Laboratory of Molecular Neuro-oncology, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.

John Fak (J)

Laboratory of Molecular Neuro-oncology, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.

Sitsandziwe Simelane (S)

Laboratory of Molecular Neuro-oncology, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.

Thomas Carroll (T)

Bioinformatics Resource Center, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.

Serge Przedborski (S)

Department of Neurology, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.
Department of Pathology & Cell Biology, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.
Department of Neuroscience, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.
ORCID: 0000-0002-7283-3883

Robert B Darnell (RB)

Laboratory of Molecular Neuro-oncology, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA. darnelr@rockefeller.edu.
Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA. darnelr@rockefeller.edu.
ORCID: 0000-0002-5134-8088

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Blood transcriptomic signatures associated...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Blood transcriptomic signatures associated...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Blood transcriptomic signatures associated...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Blood transcriptomic signatures associated...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Blood transcriptomic signatures associated...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Néostriatum › Putamen › Blood transcriptomic signatures associated...