Vitamin C as a treatment for organ failure in sepsis.
Organ failure
Pathogenesis
Pharmacological mechanism
Sepsis
Vitamin C
Journal
European journal of medical research
ISSN: 2047-783X
Titre abrégé: Eur J Med Res
Pays: England
ID NLM: 9517857
Informations de publication
Date de publication:
05 Jul 2023
05 Jul 2023
Historique:
received:
09
04
2023
accepted:
21
06
2023
medline:
7
7
2023
pubmed:
6
7
2023
entrez:
5
7
2023
Statut:
epublish
Résumé
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, with a high morbidity and mortality rate. Exogenous vitamin C supplementation is a potential therapeutic option for the treatment of multi-organ dysfunction in sepsis due to the significantly lower levels of vitamin C in the circulating blood of sepsis patients compared to healthy subjects and the importance of vitamin C in many of the physiological processes of sepsis. Vitamin C may influence the function of numerous organs and systems, including the heart, lungs, kidneys, brain, and immune defences, by reducing oxidative stress, inhibiting inflammatory factor surges, regulating the synthesis of various mediators and hormones, and enhancing immune cell function. With the development of multiple clinical randomized controlled trials, the outcomes of vitamin C treatment for critically ill patients have been discussed anew. This review's objectives are to provide an overview of how vitamin C affects various organ functions in sepsis and to illustrate how it affects each organ. Understanding the pharmacological mechanism of vitamin C and the organ damage caused by sepsis may help to clarify the conditions and clinical applications of vitamin C.
Identifiants
pubmed: 37408078
doi: 10.1186/s40001-023-01183-7
pii: 10.1186/s40001-023-01183-7
pmc: PMC10320904
doi:
Substances chimiques
Ascorbic Acid
PQ6CK8PD0R
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
222Informations de copyright
© 2023. The Author(s).
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