The potential roles of Th17 cells in the pathogenesis of oral lichen planus.
IL-17
IL-22
Lichen planus
OLP
Oral Lichen planus
Th17
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
ISSN: 1420-908X
Titre abrégé: Inflamm Res
Pays: Switzerland
ID NLM: 9508160
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
03
04
2023
accepted:
26
06
2023
revised:
24
06
2023
medline:
19
7
2023
pubmed:
7
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
Oral lichen planus (OLP) is a T cell-mediated chronic autoimmune disease, whose pathogenesis and etiology are not entirely understood. OLP is characterized by subepithelial lymphocyte infiltration and elevated intra-epithelial lymphocytes. The majority of lamina propria lymphocytes are CD4 To make up this review, studies covering the role of TH17 in different types of lichen planus were selected from major databases. As we review in this article, Th17 cells and their signature cytokines play an important role in OLP pathogenesis. As well, utilizing some anti-IL-17 antibodies showed promising results in improving the disease; however, more studies are still needed to better understand and treat OLP.
Sections du résumé
BACKGROUND
BACKGROUND
Oral lichen planus (OLP) is a T cell-mediated chronic autoimmune disease, whose pathogenesis and etiology are not entirely understood. OLP is characterized by subepithelial lymphocyte infiltration and elevated intra-epithelial lymphocytes. The majority of lamina propria lymphocytes are CD4
METHODS
METHODS
To make up this review, studies covering the role of TH17 in different types of lichen planus were selected from major databases.
RESULTS
RESULTS
As we review in this article, Th17 cells and their signature cytokines play an important role in OLP pathogenesis. As well, utilizing some anti-IL-17 antibodies showed promising results in improving the disease; however, more studies are still needed to better understand and treat OLP.
Identifiants
pubmed: 37414985
doi: 10.1007/s00011-023-01763-7
pii: 10.1007/s00011-023-01763-7
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1513-1524Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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