A primer on modelling pancreatic islets: from models of coupled β-cells to multicellular islet models.
Computational model
diabetes mellitus
gap-junctions
islets
mathematical model
paracrine
Journal
Islets
ISSN: 1938-2022
Titre abrégé: Islets
Pays: United States
ID NLM: 101495366
Informations de publication
Date de publication:
31 Dec 2023
31 Dec 2023
Historique:
medline:
10
7
2023
pubmed:
7
7
2023
entrez:
7
7
2023
Statut:
ppublish
Résumé
Pancreatic islets are mini-organs composed of hundreds or thousands of ɑ, β and δ-cells, which, respectively, secrete glucagon, insulin and somatostatin, key hormones for the regulation of blood glucose. In pancreatic islets, hormone secretion is tightly regulated by both internal and external mechanisms, including electrical communication and paracrine signaling between islet cells. Given its complexity, the experimental study of pancreatic islets has been complemented with computational modeling as a tool to gain a better understanding about how all the mechanisms involved at different levels of organization interact. In this review, we describe how multicellular models of pancreatic cells have evolved from the early models of electrically coupled β-cells to models in which experimentally derived architectures and both electrical and paracrine signals have been considered.
Identifiants
pubmed: 37415423
doi: 10.1080/19382014.2023.2231609
pmc: PMC10332213
doi:
Substances chimiques
Insulin
0
Glucagon
9007-92-5
Pancreatic Hormones
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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