Medical examiner response to the drug overdose epidemic in King County Washington: "Real-time" surveillance, data science, and applied forensic epidemiology.

applied forensic epidemiology autopsy data science drug evidence testing drug overdose epidemic fentanyl forensic pathology forensic toxicology medicolegal death investigation real-time surveillance

Journal

Journal of forensic sciences
ISSN: 1556-4029
Titre abrégé: J Forensic Sci
Pays: United States
ID NLM: 0375370

Informations de publication

Date de publication:
Sep 2023
Historique:
revised: 16 06 2023
received: 27 02 2023
accepted: 27 06 2023
medline: 6 9 2023
pubmed: 7 7 2023
entrez: 7 7 2023
Statut: ppublish

Résumé

As the overdose epidemic overwhelmed medicolegal death investigation offices and toxicology laboratories, the King County Medical Examiner's Office responded with "real-time" fatal overdose surveillance to expedite death certification and information dissemination through assembling a team including a dedicated medicolegal death investigator, an information coordinator, and student interns. In-house testing of blood, urine, and drug evidence from scenes was performed using equipment and supplies purchased for surveillance. Collaboration with state laboratories allowed validation. Applied forensic epidemiology accelerated data dissemination. From 2010 to 2022, the epidemic claimed 5815 lives in King County; the last 4 years accounted for 47% of those deaths. After initiating the surveillance project, in-house testing was performed on blood from 2836 decedents, urine from 2807, and 4238 drug evidence items from 1775 death scenes. Time to complete death certificates decreased from weeks to months to hours to days. Overdose-specific information was distributed weekly to a network of law enforcement and public health agencies. As the surveillance project tracked the epidemic, fentanyl and methamphetamine became dominant and were associated with other indicators of social deterioration. In 2022, fentanyl was involved in 68% of 1021 overdose deaths. Homeless deaths increased sixfold; in 2022, 67% of 311 homeless deaths were due to overdose; fentanyl was involved in 49% and methamphetamine in 44%. Homicides increased 250%; in 2021, methamphetamine was positive in 35% of 149 homicides. The results are relevant to the value of rapid surveillance, its impact on standard operations, selection of cases requiring autopsy, and collaboration with other agencies in overdose prevention.

Identifiants

pubmed: 37417312
doi: 10.1111/1556-4029.15329
doi:

Substances chimiques

Fentanyl UF599785JZ
Methamphetamine 44RAL3456C
Analgesics, Opioid 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1632-1642

Subventions

Organisme : Centers for Disease Control and Prevention / American Public Health Data Science Demonstration Project
Organisme : Centers for Disease Control and Prevention Overdose to Action
Organisme : Paul Coverdell Forensic Sciences Improvement Grants Program

Informations de copyright

© 2023 American Academy of Forensic Sciences.

Références

Loesche D. America has the highest drug-death rate in North America - and the world. 2017 Statista. [cited 2023 Feb 19]. Available from: https://www.statista.com/chart/9973/drug-related-deaths-and-mortality-rate-worldwide/
Hedegaard H, Miniño AM, Warner M. Drug overdose deaths in the United States, 1999-2019. 2020 NCHS Data Breif [cited 2023 Feb 19]. Available from: https://www.cdc.gov/nchs/data/databriefs/db428.pdf
Wilson N, Kariisa M, Seth P, Smith H IV, Davis NL. Drug and opioid involved overdose deaths - United States, 2017-2018. MMWR Morb Mortal Wkly Rpt. 2020;69(11):290-7. https://doi.org/10.15585/mmwr.mm6911a4
National Institutes on Drug Abuse. Drug overdose death rates. 2023 [cited 2023 Feb 19]. Available from: https://nida.nih.gov/drug-topics/opioids/opioid-overdose-crisis
Mattson CL, Tanz L, Quinn K, Kariisa M, Patel P, Davis NL. Trends and geographic patterns in drug and synthetic opioid overdose deaths - United States, 2013-2019. MMWR Morb Mortal Wkly Rpt. 2021;70:202-7. https://doi.org/10.15585/mmwr.mm7006a4
Hedegaard H, Bastian BA, Trinidad JP, Spencer MR, Warner M. Regional differences in the drugs most frequently involved in drug overdose deaths: United States, 2017. Natl Vital Stat Rep. 2019;68(12):1-12. [cited 2023 Feb 19]. Available from: https://stacks.cdc.gov/view/cdc/82186
Ministry of Public Safety & Solicitor General. Illicit drug toxicity deaths in BC January 1, 2011 - December 31, 2021. 2022 BC Coroners Service [cited 2023 Feb 19]. Available from: https://www.Vmcdn.Ca/Files/Princegeorgematters/Pgc-Files/Illicit-Drug---Sept.-30,-2021.Pdf
Baldwin N, Gray R, Anirudh G, Wood E, Buxton JA, Rieb LM. Fentanyl and heroin contained in seized illicit drugs and overdose-related death in British Columbia, Canada: an observational analysis. Drug Alcohol Depend. 2018;185:322-7. https://doi.org/10.1016/j.drugalcdep.2017.12.032
Ciccarone D. The triple wave epidemic: supply and demand drivers of the US opioid crisis. Int J Drug Policy. 2019;71:183-8. https://doi.org/10.1016/j.drugpo.2019.01.010
Jones CM, Bekheet F, Park JN, Alexander GC. The evolving overdose epidemic: synthetic opioids and rising stimulant-related harms. Epidemiol Rev. 2020;42(1):154-66. https://doi.org/10.1093/epirev/mxaa011
Midgette G, Davenport S, Caulkins JP, Kilmer B. What America's users spend on illegal drugs, 2006-2016. Santa Monica, CA: RAND Corp; 2019. https://doi.org/10.7249/RR3140
Ciccarone D. Fentanyl in the U.S. heroin supply: a rapidly changing risk environment. Int J Drug Policy. 2017;46:107-11. https://doi.org/10.1016/j.drugpo.2017.06.010
Shover CL, Falasinnu TO, Dwyer CL, Santons NB, Cunningham NJ, Freedman RB, et al. Steep increases in fentanyl-related mortality west of the Mississippi River: recent evidence from county and state surveillance. Drug Alcohol Depend. 2020;216:108314. https://doi.org/10.1016/j.drugalcdep.2020.108314
Thombs RP, Thombs DL, Jorgenson AK, Braswell TH. What is driving the drug overdose epidemic in the United States? J Health Soc Behavior. 2020;61:275-89. https://doi.org/10.1177/0022146520939514
Baldwin GT, Seth P, Noonan RK. Continued increases in overdose deaths related to synthetic opioids: implications for clinical practice. JAMA. 2021;325:1151-2. https://doi.org/10.1001/jama.2021.1169
O'Donnell J, Tanz LJ, Gladden RM, Davis NL, Bitting J. Overdose deaths involving illicitly manufactured fentanyls - United States, 2019-2020. MMWR Morb Mortal Wkly Rpt. 2021;70:1740-6. https://doi.org/10.15585/mmwr.mm7050e3
Associated Press Staff. Mexico drug seizures soared in 2020, led by an almost 500% rise in opioid smuggling. New York, NY: The Associated Press; 2021 [cited 2023 Jan 27]. Available from: https://kvia.com/news/2021/01/01/mexico-drug-seizures-soared-in-2020-led-by-almost-500-rise-in-opiod-smuggling/
United States Drug Enforcement Administration. 2020 national drug threat assessment. 2021 [cited 2023 Feb 17]. Available from: https://www.dea.gov/documents/2021/03/02/2020-national-drug-threat-assessment
Mann B. Politicians say they'll stop fentanyl smugglers. Experts say new drug war won't work. 2023 [cited 2023 Feb 21]. Available from: https://www.npr.org/2023/02/21/1158300583/fentanyl-smuggling-border-mexico-overdose-drug-war
McGinty EE, Webster DW. The roles of alcohol and drugs in firearm violence. JAMA Intern Med. 2017;177(3):324-5. https://doi.org/10.1001/jamainternmed.2016.8192
Jay J, Miratrix LW, Branas CC, Zimmerman MA, Hemenway D. Urban building demolitions, firearm violence and drug crime. J Behav Med. 2019;42(4):626-34. https://doi.org/10.1007/s10865-019-00031-6
Duke AA, Smith KMZ, Oberleitner LMS, Westphal A, McKee SA. Alcohol, drugs, and violence: a meta-meta-analysis. Psychol Violence. 2018;8(2):238-49. https://doi.org/10.1037/vio0000106
Zhong S, Yu R, Fazel S. Drug use disorders and violence: associations with individual drug categories. Epidemiol Rev. 2020;42(1):103-16. https://doi.org/10.1093/epirev/mxaa006
Drug Enforcement Administration. DEA launches new initiative to combat drug-related violence and overdoses in communities across America. 2022 [cited 2023 Feb 16]. Available from: https://www.dea.gov/press-releases/2022/02/07/
Sinclair M. The wicked problem of drug trafficking in the western hemisphere. 2021 [cited 2023 Jan 27]. Available from: https://www.brookings.edu/blog/order-from-chaos/2021/01/15/the-wicked-problem-of-drug-trafficking-in-the-western-hemisphere/
Council on Foreign Relations. Mexico's long war: drugs, crime, and the cartels. 2022 [cited 2023 Jan 27]. Available from: https://www.cfr.org/backgrounder/mexicos-long-war-drugs-crime-and-cartels
Davis GG, Cadwallader AB, Fligner CL, Gilson TP, Hall ER, Harshbarger KE, et al. Recommendations for the investigation, diagnosis, and certification of deaths related to opioid and other drugs. Am J Forensic Med Pathol. 2020;41:152-9. https://doi.org/10.1097/PAF.0000000000000550
Shute R, Bollinger K, Tucker M, Ropero-Miller JD. Use of rapid toxicology screening tools in medical examiner/coroner offices. Washington, DC: U.S. Department of Justice, Office of Investigative and Forensic Sciences; 2021. p. 1-9 [cited 2023 Feb 19]. Available from: https://forensiccoe.org/rapid-toxicology-screening-mdi/
Salomone A, Palamar JJ. Toxicosurveillance of novel opioids: just screening tests may not be enough. Am J Drug Alcohol Abuse. 2021;47(3):271-2. https://doi.org/10.1080/00952990.2021.1917588
McMillin GA, Johnson-Davis KL, Kelly BN, Scott B, Yang YK. Impact of the opioid epidemic on drug testing. Ther Drug Monit. 2021;43:14-24. https://doi.org/10.1097/FTD.0000000000000841
Ropero Miller JD, Mullen LD, Speaker PJ. The sentinel role of forensic toxicology laboratories to identify and act upon diverse drug threats by addressing toxicology and economic demands. Forensic Sci Int Synergy. 2022;5:10092. https://doi.org/10.1016/j.fsisyn.2022.100292
Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. OD2A: surveillance. 2022 [cited 2023 Feb 16]. Available from: https://www.cdc.gov/drugoverdose/od2a/surveillance.html
Marshall BDL, Milloy M, Wood E, Montaner JSG, Kerr T. Reduction in overdose mortality after the opening of North America's first medically supervised safer injecting facility: a retrospective population-based study. Lancet. 2011;377(9775):1429-37. https://doi.org/10.1016/S0140-6736(10)62353-7
Frank RG, Pollack HA. Addressing the fentanyl threat to public health. N Engl J Med. 2017;376(7):605-7. https://doi.org/10.1056/NEJMp1615145
Lovrecic B, Lovrecic M, Gabrovex B, Carli M, Pacini M, Maremmani AGI, et al. Non-medical use of novel synthetic opioids: a new challenge to public health. Int J Environ Res Public Health. 2019;16(2):177. https://doi.org/10.3390/ijerph16020177
Razaghizad A, Windle SB, Filion KB, Gore G, Kudrina I, Paraskevopoulos E, et al. The effect of overdose education and naloxone distribution: an umbrella review of systematic reviews. Am J Public Health. 2021;111(8):e1-e12. https://doi.org/10.2105/AJPH.2021.306306
Milaney K, Passi J, Zaretsky L, Liu T, O'Gorman CM, Hill L, et al. Drug use, homelessness and health: responding to the opioid overdose crisis with housing and harm reduction services. Harm Reduct J. 2021;18(1):92. https://doi.org/10.1186/s12954-021-00539-8
Scott R, Marchand M, Stover B, Causey K, Harruff R, Hagopian A. Without shelter, people die: disproportionate mortality among King County's homeless population, 2009-2019. J Soc Distress Homeless. 2022;1-11. https://doi.org/10.1080/10530789.2021.2021360
Patrick A. More homeless people died in King County in 2022 than ever recorded before. 2023 The Seattle Times [cited 2023 Feb 16]. Available from: https://www.seattletimes.com/seattle-news/homeless/more-homeless-people-died-in-king-county-in-2022-than-ever-recorded-before
Associated press staff. Fentanyl fuels record homeless deaths in Seattle area. 2023 The Washington Examiner [cited 2023 Feb 16]. Available from: https://www.washingtonexaminer.com/news/fentanyl-fuels-record-homeless-deaths-in-seattle-area
United States Sentencing Commission. Quick facts: drug trafficking offenses 2016-2020. [cited 2023 Jan 27]. Available from: https://www.ussc.gov/sites/default/files/pdf/research-and-publications/quickfacts/Drug_Trafficking_FY20.pdf
National Institute on Drug Abuse. Criminal justice DrugFacts. 2020 [cited 2023 Feb 16]. Available from: https://nida.nih.gov/publications/drugfacts/criminal-justice
Mantha S, Nolan ML, Harocopos A, Paone D. Racial disparities in criminal legal system involvement among new York City overdose decedents: implications for diversion programs. J Alcohol Drug Depend. 2021;226:108867. https://doi.org/10.1016/j.drugalcdep.2021.108867
Brinkley-Rubinstein L, Zaller N, Martino S, Cloud DH, McCauley E, Heise A, et al. Criminal justice continuum, for opioid users at risk of overdose. Addict Behav. 2018;86:104-10. https://doi.org/10.1016/j.addbeh.2018.02.024
Mallgrave A. Purely local tragedies: how prosecuting drug-induced homicide in federal court exacerbates the overdose crisis. Drexel L Rev. 2021;13:233-76.
Phillips KS. From overdose to crime scene: the incompatibility of drug induced homicide statues with due process. Duke Law J. 2020;70:659-704.
Centers for Disease Control and Prevention. CDC's state unintentional drug overdose reporting system (SUDORS). 2022 [cited 2023 Feb 16]. Available from: https://www.cdc.gov/drugoverdose/fatal/sudors.html
Centers of Disease Control and Prevention. Vital statistics rapid release: provisional drug overdose death counts. [cited 2023 Feb 16]. Available from: https://www.cdc.gov/nchs/nvss/vsrr/drug-overdose-data.htm
Mann B. After 50 years of the war on drugs, ‘what good is it doing for us?’. 2021 [cited 2023 Jan 27]. Available from: https://www.npr.org/2021/06/17/1006495476/after-50-years-of-the-war-on-drugs-what-good-is-it-doing-for-us
Davis C, Green T, LaSalle L, Beletsky L. State approaches to addressing the overdose epidemic. J Law Med Ethics. 2019;47(2):43-6. https://doi.org/10.1177/1073110519857315
Drug Policy Alliance. About us - 2022. [cited 2023 Feb 16]. Available from: https://drugpolicy.org/about/
Drug Policy Alliance. State-by-state laws. [cited 2023 Feb 16]. Available from: https://drugpolicy.org/decrim/laws
Pawliuk C, Park M, Buxton JA. Legal approaches and government policies enacted to address the overdose epidemic: a scoping review protocol. JBI Evid Synth. 2021;19(1):184-200. https://doi.org/10.11124/JBISRIR-D-19-00296
Friedman LS. Real-time surveillance of illicit drug overdoses using poison center data. Clin Toxicol. 2009;47:573-9. https://doi.org/10.1080/15563650902967404
Lucyk SN, Nelson LS. Toxicosurveillance in the US opioid epidemic. Int J Drug Policy. 2017;46:168-71. https://doi.org/10.1016/j.drugpo.2017.05.057
Horon IL, Singal P, Fowler DR, Sharfstein JM. Standard death certificate versus enhanced surveillance to identify heroin overdose-related deaths. Am J Public Health. 2018;108:777-81. https://doi.org/10.2105/AJPH.2018.304385
Morrow JB, Ropero-Miller JD, Catlin ML, Winokur AD, Cadwallader AB, Staymates JL, et al. The opioid epidemic: moving toward an integrated, holistic analytical response. J Anal Toxicol. 2019;43(1):1-9. https://doi.org/10.1093/jat/bky049
Hoots BE. Opioid overdose surveillance: improving data to inform action. Public Health Rep. 2021;136:5S-8S. https://doi.org/10.1177/00333549211020275
O'Donnell J, Gladden RM, Kariisa M, Mattson CL. Using death scene and toxicology evidence to define involvement of heroin, pharmaceutical morphine, illicitly manufactured fentanyl and pharmaceutical fentanyl in opioid overdose deaths, 38 states and the District of Columbia, January 2018-December 2019. Addiction. 2022;117(5):1483-90. https://doi.org/10.1111/add.15768
Kerensky T, LaRochelle M, Fan S-L, Kosakowski S, Wason K, Walley AY. Non-prescription fentanyl positive toxicology: prevalence, positive predictive value of fentanyl immunoassay screening, and description of co-substance use. J Addict Med. 2021;15:150-4. https://doi.org/10.1097/ADM.0000000000000723
Fiorentin TR, Krotulski AJ, Marin DM, Browne T, Triplett J, Conti T, et al. Detection of cutting agents in drug-positive seized exhibits within the United States. J Forensic Sci. 2019;64(3):888-96. https://doi.org/10.1111/1556-4029.13968
Fiorentin TR, Logan BK. Analytical findings in used syringes from a syringe exchange program. Int J Drug Policy. 2020;81:102770. https://doi.org/10.1016/j.drugpo.2020.102770
Glicksberg L, Dempsey SK, Casey BK. Heroin and fentanyl in Dallas County: a 5-year retrospective review of toxicological, seized drug, and demographical data. J Forensic Sci. 2023;68(1):222-32. https://doi.org/10.1111/1556-0034029.15155
Vannice K, Hood J, Yarid N, Kay M, Harruff R, Duchin J. Accuracy of medical examiner's assessment for near-real-time surveillance of fatal drug overdoses, King County, Washington, march 2017-February 2018. Public Health Rep. 2022;137:463-70. https://doi.org/10.1177/00333549211008455
Harruff RC, Couper FJ, Banta-Green CJ. Tracking the opioid drug overdose epidemic in King County, Washington using an improved methodology for certifying heroin related deaths. Acad Forensic Pathol. 2015;5:499-506. https://doi.org/10.23907/2015.055
Harruff RC, Simpson CM, Gifford AL, Yarid N, Barbour WL, Heidere C. Evaluation of “real-time” fatal drug overdose surveillance by King County medical Examiner's office, Seattle, Washington. Am J Forensic Med Pathol. 2023;44:11-6. https://doi.org/10.1097/PAF.0000000000000798
Washington State Office of the Attorney General. Homicide investigation tracking system (HITS). [cited 2023 Feb 19]. Available from: https://www.atg.wa.gov/homicide-investigation-tracking-system-hits
Silge J, Robinson D. Text mining with R: a tidy approach. Sebastopol, CA: O'Reilly Media; 2017 [cited 2023 Feb 16]. Available from: https://www.tidytextmining.com/index.html
National Association of Medical Examiners. Inspection and accreditation policies and procedures. 2017 [cited 2023 Feb 23]. Available from: 1d082f4f-e2a4-4a84-91b7-a8eb1ae089ee.pdf (memberclicks.net)
Dye WD, McGwin G, Atherton DS, McClesky B, Davis GG. Correctly identifying deaths due to drug toxicity without a forensic autopsy. Am J Forensic Med Pathol. 2019;40:99-101. https://doi.org/10.1097/PAF.0000000000000465
US Department of Justice. Report to congress: needs assessment of forensic laboratories and medical examiner/coroner offices. 2019 [cited 2023 May 4]. Available from: https://www.justice.gov/olp/page/file/1228306/download
Open Access Government. Shortages in medicolegal death investigation. 2021 [cited 2023 May 4]. Available from: https://www.openaccessgovernment.org/medicolegal-death/124398/
Imtiaz S, Nafeh F, Russell C, Ali F, Elton-Marshall T, Rehm J. The impact of the novel coronavirus disease (COVID-19) pandemic on drug overdose related deaths in the United States and Canada: a systematic review of observational studies and analysis of public health surveillance data. Subst Abuse Treat Prev Policy. 2021;16:87. https://doi.org/10.1186/s13011-021-00423-5
DiGennaro C, Garcia GP, Stringfellow EJ, Wakeman S, Jalali MS. Changes in characteristics of drug overdose death trends during the COVID-19 pandemic. Int J Drug Policy. 2021;98:103392. https://doi.org/10.1016/j.drugpo.2021.103392
Tanz LJ, Dinwiddie AT, Snodgrass S, O'Donnell J, Mattson CL, Davis NL. A qualitative assessment of circumstances surrounding drug overdose deaths during the early stages of the COVID-19 pandemic. Atlanta, GA: Centers for Disease Control; 2022 [cited 2023 Feb 16]. Available from: https://www.cdc.gov/drugoverdose/databriefs/sudors-2.html#_ftn1
Washington State Legislature. SB 5476-2021-22. [cited 2023 Feb 20]. Available from: https://app.leg.wa.gov/billsummary?BillNumber=5476&Year=2021
Centers for Disease Control and Prevention, National Center for Health Statistics. Collaborating Office for Medical Examiners and Coroners (COMEC). 2023 [cited 2023 Feb 19]. Available from: https://www.cdc.gov/nchs/comec/index.htm
Council of State and Territorial Epidemiologist. Applied forensic epidemiology in medical examiner and coroner offices. 2022 [cited 2023 May 4]. Available from: https://www.cste.org/general/custom.asp?page=appliedforensic
Public Health - Seattle & King County. King County medical Examiner's office. 2022 [cited 2023 Feb 19]. Available from: https://kingcounty.gov/depts/health/examiner.aspx
Berry SD, Edgar HJH. Extracting and standardizing medical examiner data to improve health. AMIA Jt Summits Transl Sci Proc. 2020;2020:63-70.
Goodman-Meza D, Shover CL, Medina JA, Tang AB, Shoptaw S, Bui AA. Development and validation of machine models using natural language processing to classify substances involved in overdose and deaths. JAMA Netw Open. 2022;5(8):e2225593. https://doi.org/10.1001/jamanetworkopen.2022.25593
Grassel J, McKay J. Medicolegal death investigation partnerships on overdose fatality reviews. 2022 Forensic Technology Center of Excellence and U.S. Department of Justice, National Institute of Justice, Office of Investigative and Forensic Sciences [cited 2023 Feb 19]. Available from: https://forensiccoe.org/report-2022-mdi-partnerships-ofr/

Auteurs

Richard C Harruff (RC)

King County Medical Examiner's Office, Seattle, Washington, USA.

Nicole A Yarid (NA)

King County Medical Examiner's Office, Seattle, Washington, USA.

William L Barbour (WL)

King County Medical Examiner's Office, Seattle, Washington, USA.

Yang H Martin (YH)

King County Medical Examiner's Office, Seattle, Washington, USA.

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