Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties.

Humans Mice Animals RNA Cell Line Leukemia, Myeloid, Acute / drug therapy Structure-Activity Relationship Genes, myc Alpha-Ketoglutarate-Dependent Dioxygenase FTO / genetics

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
27 07 2023
Historique:
medline: 28 7 2023
pubmed: 7 7 2023
entrez: 7 7 2023
Statut: ppublish

Résumé

The fat mass and obesity-associated protein (FTO) is an RNA

Identifiants

DOI: 10.1021/acs.jmedchem.3c00543 PMID: 37418628
pubmed: 37418628
doi: 10.1021/acs.jmedchem.3c00543
doi:

Substances chimiques

RNA 63231-63-0
Alpha-Ketoglutarate-Dependent Dioxygenase FTO EC 1.14.11.33
FTO protein, human EC 1.14.11.33
FTO protein, mouse EC 1.14.11.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9731-9752

Auteurs

Pan Xiao (P)

School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Zongliang Duan (Z)

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Zeyu Liu (Z)

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
University of Chinese Academy of Sciences, Beijing 100049, China.

Liang Chen (L)

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
University of Chinese Academy of Sciences, Beijing 100049, China.

Deyan Zhang (D)

School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
University of Chinese Academy of Sciences, Beijing 100049, China.

Lu Liu (L)

School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Chen Zhou (C)

Analytical Research Center for Organic and Biological Molecules, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Jianhua Gan (J)

School of Life Sciences, Fudan University, Shanghai 200433, China.
ORCID: 0000-0002-8438-8852

Ze Dong (Z)

School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
ORCID: 0000-0003-4876-415X

Cai-Guang Yang (CG)

School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
ORCID: 0000-0001-5778-4422

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Rational Design of RNA Demethylase FTO...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Rational Design of RNA Demethylase FTO...
questionsmedicales.fr › Eucaryotes › Animaux › Rational Design of RNA Demethylase FTO...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Rational Design of RNA Demethylase FTO...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Rational Design of RNA Demethylase FTO...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › Rational Design of RNA Demethylase FTO...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Rational Design of RNA Demethylase FTO...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Oncogènes › Proto-oncogènes › Gènes myc › Rational Design of RNA Demethylase FTO...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › AlkB enzymes › Alpha-ketoglutarate-dependent dioxygenase FTO › Rational Design of RNA Demethylase FTO...