Lactose in tablets: Functionality, critical material attributes, applications, modifications and co-processed excipients.

Excipients Lactose Tablets Solubility Drug Compounding / methods
co-processed excipient critical material attributes critical quality attributes lactose modification quality by design tablet

Journal

Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391

Informations de publication

Date de publication:
09 2023
Historique:
received: 01 02 2023
revised: 06 06 2023
accepted: 29 06 2023
medline: 4 9 2023
pubmed: 8 7 2023
entrez: 7 7 2023
Statut: ppublish

Résumé

Lactose is one of the most widespread excipients used in the pharmaceutical industry. Because of its water solubility and acceptable flowability, lactose is generally added into tablet formulation to improve wettability and undesirable flowability. Based on Quality by Design, a better understanding of the critical material attributes (CMAs) of raw materials is beneficial in guiding the improvement of tablet quality and the development of lactose. Additionally, the modifications and co-processing of lactose can introduce more-desirable characteristics to the resulting particles. This review focuses on the functionality, CMAs, applications, modifications and co-processing of lactose in tablets.

Identifiants

DOI: 10.1016/j.drudis.2023.103696 PMID: 37419210
pubmed: 37419210
pii: S1359-6446(23)00212-X
doi: 10.1016/j.drudis.2023.103696
pii:
doi:

Substances chimiques

Excipients 0
Lactose J2B2A4N98G
Tablets 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103696

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Auteurs

Chuting Shi (C)

Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine of Ministry of Education, Shanghai University of Traditional Chinese Medicine, No. 1200, Cai-lun Road, Pudong District, Shanghai 201203, PR China.

Haiyue Zhao (H)

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cai-lun Road, Pudong District, Shanghai 201203, PR China.

Ying Fang (Y)

Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine of Ministry of Education, Shanghai University of Traditional Chinese Medicine, No. 1200, Cai-lun Road, Pudong District, Shanghai 201203, PR China.

Lan Shen (L)

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cai-lun Road, Pudong District, Shanghai 201203, PR China. Electronic address: alansusu@sina.com.

Lijie Zhao (L)

Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine of Ministry of Education, Shanghai University of Traditional Chinese Medicine, No. 1200, Cai-lun Road, Pudong District, Shanghai 201203, PR China. Electronic address: 0000002383@shutcm.edu.cn.

Articles similaires

Bioefficiency of microencapsulated hemp leaf phytonutrient-based extracts to enhance in vitro rumen fermentation and mitigate methane production.

Srisan Phupaboon, Maharach Matra, Ronnachai Prommachart et al.
1.00
Animals Rumen Methane Fermentation Cannabis

Time to consider ruling out inclusion bodies denaturing protocols for spontaneous solubilization of biologically active proteins.

Ricardo Baltà-Foix, Elena Garcia-Fruitós, Anna Arís
1.00
Inclusion Bodies Solubility Recombinant Proteins Detergents Protein Denaturation

Elucidating ATP's role as solubilizer of biomolecular aggregate.

Susmita Sarkar, Saurabh Gupta, Chiranjit Mahato et al.
1.00
Adenosine Triphosphate Protein Aggregates Solubility Humans Protein Conformation

Fluorescent and colorimetric dual-mode recognition of Al

Liping Lin, Meng Fang, Yaojia Lin et al.
1.00
Colorimetry Hydrogen-Ion Concentration Tablets Aluminum Nitrogen

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Excipients pharmaceutiques › Excipients › Lactose in tablets: Functionality, critical...
questionsmedicales.fr › Glucides › Sucres › Diholoside › Lactose › Lactose in tablets: Functionality, critical...
questionsmedicales.fr › Préparations pharmaceutiques › Comprimés › Lactose in tablets: Functionality, critical...
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Lactose in tablets: Functionality, critical...
questionsmedicales.fr › Techniques d'investigation › Préparation de médicament › Lactose in tablets: Functionality, critical...