Mitochondria as intracellular signalling organelles. An update.

Mitochondria / metabolism Oxidative Stress / physiology Signal Transduction / physiology Oxidation-Reduction DNA, Mitochondrial / metabolism
Mitochondriopathies Mitophagy Oxidative stress Signal transduction mtDNA

Journal

Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683

Informations de publication

Date de publication:
09 2023
Historique:
received: 08 05 2023
revised: 23 06 2023
accepted: 02 07 2023
medline: 28 7 2023
pubmed: 9 7 2023
entrez: 8 7 2023
Statut: ppublish

Résumé

Traditionally, mitochondria are known as "the powerhouse of the cell," responsible for energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the tricarboxylic acid cycle, and fatty acid ß-oxidation), and for the regulation of several metabolic processes, including redox homeostasis, calcium signalling, and cellular apoptosis. The extensive studies conducted in the last decades portray mitochondria as multifaceted signalling organelles that ultimately command cells' survival or death. Based on current knowledge, we'll outline the mitochondrial signalling to other intracellular compartments in homeostasis and pathology-related mitochondrial stress conditions here. The following topics are discussed: (i) oxidative stress and mtROS signalling in mitohormesis, (ii) mitochondrial Ca

Identifiants

DOI: 10.1016/j.cellsig.2023.110794 PMID: 37422005
pubmed: 37422005
pii: S0898-6568(23)00208-5
doi: 10.1016/j.cellsig.2023.110794
pii:
doi:

Substances chimiques

DNA, Mitochondrial 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110794

Informations de copyright

Copyright © 2023 The Author. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest There is no conflict of interest.

Auteurs

Lucia-Doina Popov (LD)

Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, 8, B.P. Hasdeu Street, 050568 Bucharest, Romania. Electronic address: doina.popov@icbp.ro.

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondria as intracellular signalling...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Mitochondria as intracellular signalling...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Mitochondria as intracellular signalling...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Mitochondria as intracellular signalling...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN mitochondrial › Mitochondria as intracellular signalling...