The Role of Gut Microbiome-Derived Short-Chain Fatty Acid Butyrate in Hepatobiliary Diseases.
Journal
The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
29
03
2023
revised:
09
06
2023
accepted:
21
06
2023
pmc-release:
01
10
2024
medline:
19
9
2023
pubmed:
9
7
2023
entrez:
8
7
2023
Statut:
ppublish
Résumé
The short-chain fatty acid butyrate, produced from fermentable carbohydrates by gut microbiota in the colon, has multiple beneficial effects on human health. At the intestinal level, butyrate regulates metabolism, helps in the transepithelial transport of fluids, inhibits inflammation, and induces the epithelial defense barrier. The liver receives a large amount of short-chain fatty acids via the blood flowing from the gut via the portal vein. Butyrate helps prevent nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, inflammation, cancer, and liver injuries. It ameliorates metabolic diseases, including insulin resistance and obesity, and plays a direct role in preventing fatty liver diseases. Butyrate has different mechanisms of action, including strong regulatory effects on the expression of many genes by inhibiting the histone deacetylases and modulating cellular metabolism. The present review highlights the wide range of beneficial therapeutic and unfavorable adverse effects of butyrate, with a high potential for clinically important uses in several liver diseases.
Identifiants
pubmed: 37422149
pii: S0002-9440(23)00238-9
doi: 10.1016/j.ajpath.2023.06.007
pmc: PMC10548274
pii:
doi:
Substances chimiques
Butyrates
0
Fatty Acids, Volatile
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1455-1467Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK132781
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2023 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.
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