Neuronal wiring diagram of an adult brain.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
11 Jul 2023
Historique:
pubmed: 10 7 2023
medline: 10 7 2023
entrez: 10 7 2023
Statut: epublish

Résumé

Connections between neurons can be mapped by acquiring and analyzing electron microscopic (EM) brain images. In recent years, this approach has been applied to chunks of brains to reconstruct local connectivity maps that are highly informative, yet inadequate for understanding brain function more globally. Here, we present the first neuronal wiring diagram of a whole adult brain, containing 5×10

Identifiants

pubmed: 37425937
doi: 10.1101/2023.06.27.546656
pmc: PMC10327113
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NINDS NIH HHS
ID : RF1 NS121911
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : U24 NS126935
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH129268
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH120679
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH117815
Pays : United States

Déclaration de conflit d'intérêts

Competing interests T. Macrina, K. Lee, S. Popovych, D. Ih, N. Kemnitz, and H. S. Seung declare financial interests in Zetta AI.

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Auteurs

Sven Dorkenwald (S)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.
Computer Science Department, Princeton University, Princeton, USA.

Arie Matsliah (A)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Amy R Sterling (AR)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.
Eyewire, Boston, USA.

Philipp Schlegel (P)

Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.

Szi-Chieh Yu (SC)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Claire E McKellar (CE)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Albert Lin (A)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.
Center for the Physics of Biological Function, Princeton University, Princeton, USA.

Marta Costa (M)

Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.

Katharina Eichler (K)

Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.

Yijie Yin (Y)

Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.

Will Silversmith (W)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Casey Schneider-Mizell (C)

Allen Institute for Brain Science, Seattle, USA.

Chris S Jordan (CS)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Derrick Brittain (D)

Allen Institute for Brain Science, Seattle, USA.

Akhilesh Halageri (A)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Kai Kuehner (K)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Oluwaseun Ogedengbe (O)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Ryan Morey (R)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Jay Gager (J)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Krzysztof Kruk (K)

Eyewire, Boston, USA.

Eric Perlman (E)

Yikes LLC, Baltimore, USA.

Runzhe Yang (R)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.
Computer Science Department, Princeton University, Princeton, USA.

David Deutsch (D)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.
Department of Neurobiology, University of Haifa, Haifa, Israel.

Doug Bland (D)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Marissa Sorek (M)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.
Eyewire, Boston, USA.

Ran Lu (R)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Thomas Macrina (T)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.
Computer Science Department, Princeton University, Princeton, USA.

Kisuk Lee (K)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.
Brain & Cognitive Sciences Department, Massachusetts Institute of Technology, Cambridge, USA.

J Alexander Bae (JA)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.
Electrical and Computer Engineering Department, Princeton University, Princeton, USA.

Shang Mu (S)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Barak Nehoran (B)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.
Computer Science Department, Princeton University, Princeton, USA.

Eric Mitchell (E)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Sergiy Popovych (S)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.
Computer Science Department, Princeton University, Princeton, USA.

Jingpeng Wu (J)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Zhen Jia (Z)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Manuel Castro (M)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Nico Kemnitz (N)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Dodam Ih (D)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Alexander Shakeel Bates (AS)

Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Harvard Medical School, Boston, USA.
Centre for Neural Circuits and Behaviour, The University of Oxford, Oxford, UK.

Nils Eckstein (N)

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, USA.

Jan Funke (J)

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, USA.

Forrest Collman (F)

Allen Institute for Brain Science, Seattle, USA.

Davi D Bock (DD)

Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, USA.

Gregory S X E Jefferis (GSXE)

Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.

H Sebastian Seung (HS)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.
Computer Science Department, Princeton University, Princeton, USA.

Mala Murthy (M)

Princeton Neuroscience Institute, Princeton University, Princeton, USA.

Classifications MeSH