[The effect of intraperitoneal administration of dexamethasone on postoperative analgesia after laparoscopic cholecystectomy: a prospective randomized controlled double-blind study].
Intérêt de la déxaméthasone en intrapéritonéale dans l’analgésie post cholécystectomie laparoscopique: étude prospective contrôlée randomisée en double aveugle.
Dexamethasone
intraperitoneal
laparoscopic cholecystectomy
postoperative analgesia
Journal
The Pan African medical journal
ISSN: 1937-8688
Titre abrégé: Pan Afr Med J
Pays: Uganda
ID NLM: 101517926
Informations de publication
Date de publication:
2023
2023
Historique:
received:
22
07
2022
accepted:
01
04
2023
medline:
11
7
2023
pubmed:
10
7
2023
entrez:
10
7
2023
Statut:
epublish
Résumé
the effect of intravenous corticosteroids on postoperative pain has been well demonstrated; however, few studies have focused on the efficacy of intraperitoneal corticosteroid use after laparoscopic surgery. The purpose of this study was to evaluate the effect of intraperitoneal administration of dexamethasone on postoperative analgesia after laparoscopic cholecystectomy. we conducted a prospective, randomised, double-blind, controlled study, including patients scheduled for laparoscopic cholecystectomy and randomised into two groups: the group D (receiving 16 ml: 12 ml saline and 4 ml solution containing 16mg dexamethasone) and the group T (receiving 16 ml saline). The primary endpoint was: Visual Analogue Scale (VAS) for abdominal pain during the first 24 hours after surgery. The secondary endpoints were the incidence of shoulder pain, time to first request for analgesia, the consumption of morphine in the post-intervention surveillance room (PACU), the consumption of non-opioid analgesics and the incidence of nausea and vomiting during the first 24 hours after surgery as well as the presence of complications. sixty patients were included in the study and divided into two groups of 30. Demographic parameters, duration of surgical and anesthesia procedures, as well as intraoperative fentanyl consumption were comparable between the two groups. Abdominal pain VAS values (p≤0.001), the incidence of shoulder pain (p<0.001), opioid and analgesic consumption (p<0.001) and the incidence of nausea (p=0.002) and vomiting (p=0.012) during the first 24 hours after surgery were significantly lower in group D. No complications related to dexamethasone administration were noted. intraperitoneal dexamethasone reduces postoperative pain after laparoscopic cholecystectomy.
Identifiants
pubmed: 37426459
doi: 10.11604/pamj.2023.45.14.36438
pii: PAMJ-45-14
pmc: PMC10323815
doi:
Substances chimiques
Analgesics, Opioid
0
Dexamethasone
7S5I7G3JQL
Types de publication
Randomized Controlled Trial
English Abstract
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
14Informations de copyright
Copyright: Ahmed Abdelhedi et al.
Déclaration de conflit d'intérêts
Les auteurs ne déclarent aucun conflit d´intérêts.
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