Mechanisms of adaptive hypertrophic cardiac remodeling in a large animal model of premature ventricular contraction-induced cardiomyopathy.

Animals Dogs Ventricular Premature Complexes / complications Ventricular Remodeling Cardiomyopathies Disease Models, Animal Hypertrophy / complications
angiogenesis cardiac arrhythmia compensatory hypertrophy signal transduction

Journal

IUBMB life
ISSN: 1521-6551
Titre abrégé: IUBMB Life
Pays: England
ID NLM: 100888706

Informations de publication

Date de publication:
11 2023
Historique:
received: 05 03 2023
accepted: 13 06 2023
pmc-release: 01 11 2024
medline: 12 10 2023
pubmed: 10 7 2023
entrez: 10 7 2023
Statut: ppublish

Résumé

Frequent premature ventricular contractions (PVCs) promoted eccentric cardiac hypertrophy and reduced ejection fraction (EF) in a large animal model of PVC-induced cardiomyopathy (PVC-CM), but the molecular mechanisms and markers of this hypertrophic remodeling remain unexplored. Healthy mongrel canines were implanted with pacemakers to deliver bigeminal PVCs (50% burden with 200-220 ms coupling interval). After 12 weeks, left ventricular (LV) free wall samples were studied from PVC-CM and Sham groups. In addition to reduced LV ejection fraction (LVEF), the PVC-CM group showed larger cardiac myocytes without evident ultrastructural alterations compared to the Sham group. Biochemical markers of pathological hypertrophy, such as store-operated Ca

Identifiants

DOI: 10.1002/iub.2765 PMID: 37427864 PMC: PMC10592397
pubmed: 37427864
doi: 10.1002/iub.2765
pmc: PMC10592397
mid: NIHMS1915710
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

926-940

Subventions

Organisme : BLRD VA
ID : I01 BX004861
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016059
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR068431
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139874
Pays : United States

Informations de copyright

© 2023 The Authors. IUBMB Life published by Wiley Periodicals LLC on behalf of International Union of Biochemistry and Molecular Biology.

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Auteurs

Jaime Balderas-Villalobos (J)

Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

J M Lourdes Medina-Contreras (JML)

Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

Christopher Lynch (C)

Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

Rajiv Kabadi (R)

Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.

Janée Hayles (J)

Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.

Rafael J Ramirez (RJ)

Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

Alex Y Tan (AY)

Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia, USA.

Karoly Kaszala (K)

Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia, USA.

Montserrat Samsó (M)

Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

Jose F Huizar (JF)

Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia, USA.

Jose M Eltit (JM)

Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
ORCID: 0000-0002-5288-1669

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Classifications MeSH

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questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Extrasystoles › Extrasystoles ventriculaires › Mechanisms of adaptive hypertrophic cardiac...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Fonction ventriculaire › Remodelage ventriculaire › Mechanisms of adaptive hypertrophic cardiac...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Cardiomyopathies › Mechanisms of adaptive hypertrophic cardiac...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Mechanisms of adaptive hypertrophic cardiac...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Hypertrophie › Mechanisms of adaptive hypertrophic cardiac...