Beyond Neoantigens: Antigens Derived from Tumor Drivers as Cancer Vaccine Targets.
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 09 2023
01 09 2023
Historique:
received:
16
05
2023
revised:
28
05
2023
accepted:
27
06
2023
medline:
4
9
2023
pubmed:
10
7
2023
entrez:
10
7
2023
Statut:
ppublish
Résumé
A vaccine targeting HER2, a nonmutated but overexpressed tumor antigen, readily primed T cells for ex vivo expansion and adoptive transfer with minimal toxicity. This regimen led to intramolecular epitope spreading in a majority of patients and offers a treatment modality that may improve outcomes for patients with metastatic breast cancer expressing HER2. See related article by Disis et al., p. 3362.
Identifiants
pubmed: 37428103
pii: 727705
doi: 10.1158/1078-0432.CCR-23-1244
pmc: PMC10472089
doi:
Substances chimiques
Cancer Vaccines
0
Receptor, ErbB-2
EC 2.7.10.1
Antigens, Neoplasm
0
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
3256-3258Commentaires et corrections
Type : CommentOn
Informations de copyright
©2023 The Authors; Published by the American Association for Cancer Research.
Références
Cancer Immunol Res. 2019 Jul;7(7):1148-1161
pubmed: 31088845
Clin Cancer Res. 2022 Apr 14;28(8):1487-1492
pubmed: 34916216
Clin Cancer Res. 2019 May 1;25(9):2725-2736
pubmed: 30635338
Clin Breast Cancer. 2010 Oct 1;10(5):392-7
pubmed: 20920984
Clin Cancer Res. 2023 Sep 1;29(17):3362-3371
pubmed: 37093223
Clin Cancer Res. 2020 Sep 1;26(17):4670-4681
pubmed: 32732224
Breast. 2022 Dec;66:217-226
pubmed: 36334569
Nat Genet. 2020 Jul;52(7):701-708
pubmed: 32424352
Mol Ther. 2010 Apr;18(4):843-51
pubmed: 20179677
N Engl J Med. 2012 Jan 12;366(2):109-19
pubmed: 22149875
Lancet Oncol. 2022 Dec;23(12):1558-1570
pubmed: 36400106
Nat Commun. 2020 Oct 6;11(1):5017
pubmed: 33024122
N Engl J Med. 2001 Mar 15;344(11):783-92
pubmed: 11248153