Conversion of Hydroxyproline "Doubly Customizable Units" to Hexahydropyrimidines: Access to Conformationally Constrained Peptides.


Journal

The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R

Informations de publication

Date de publication:
21 07 2023
Historique:
medline: 27 7 2023
pubmed: 10 7 2023
entrez: 10 7 2023
Statut: ppublish

Résumé

The efficient transformation of hydroxyproline "doubly customizable units" into rigid hexahydropyrimidine units takes place in good global yields and generates compounds of pharmaceutical interest. In particular, the process can readily provide access to peptidomimetics and peptides with reversed sequences or with valuable turns.

Identifiants

pubmed: 37429014
doi: 10.1021/acs.joc.3c00673
pmc: PMC10367070
doi:

Substances chimiques

Hydroxyproline RMB44WO89X
Peptides 0
Peptidomimetics 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9910-9919

Références

J Org Chem. 1997 May 2;62(9):2853-2860
pubmed: 11671648
J Antibiot (Tokyo). 2013 May;66(5):281-4
pubmed: 23340663
J Org Chem. 2019 Jul 5;84(13):8392-8410
pubmed: 31120247
Chem Rev. 2011 Feb 9;111(2):657-87
pubmed: 20843067
Org Lett. 2018 Jun 15;20(12):3566-3569
pubmed: 29799207
Chem Biol Drug Des. 2019 May;93(5):724-736
pubmed: 30582286
Amino Acids. 2022 Jun;54(6):955-966
pubmed: 35414005
Angew Chem Int Ed Engl. 2019 Dec 19;58(52):19073-19080
pubmed: 31617285
J Org Chem. 1997 May 2;62(9):2847-2852
pubmed: 11671647
J Org Chem. 2015 Oct 2;80(19):9379-91
pubmed: 26151417
J Org Chem. 2009 Jul 3;74(13):4655-65
pubmed: 19391617
J Pept Sci. 2022 Jun;28(6):e3384
pubmed: 34889485
Chem Rev. 2020 Sep 9;120(17):9743-9789
pubmed: 32786420
J R Soc Interface. 2007 Aug 22;4(15):587-606
pubmed: 17251160
Org Biomol Chem. 2014 Jul 7;12(25):4479-90
pubmed: 24849849
J Am Chem Soc. 2009 Apr 29;131(16):5956-65
pubmed: 19341285
Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11067-72
pubmed: 19541614
Chirality. 2020 Sep;32(9):1160-1168
pubmed: 32621328
Chem Rev. 1998 Apr 2;98(2):763-796
pubmed: 11848914
Bioorg Med Chem Lett. 2001 Apr 23;11(8):1009-13
pubmed: 11327577
Biopolymers. 2005;80(2-3):67-84
pubmed: 15729688
Chem Rev. 2001 Oct;101(10):3131-52
pubmed: 11710065
J Org Chem. 2021 Feb 5;86(3):2796-2809
pubmed: 33433228
J Med Chem. 2002 Jun 6;45(12):2512-9
pubmed: 12036359
Org Lett. 2015 Jun 19;17(12):2980-3
pubmed: 26035233
Int J Mol Sci. 2021 Aug 12;22(16):
pubmed: 34445382
J Org Chem. 2012 Jul 20;77(14):5907-13
pubmed: 22775557
Chem Commun (Camb). 2015 Mar 14;51(21):4496-8
pubmed: 25683594

Auteurs

Dácil Hernández (D)

Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Fco. Sánchez, 3, La Laguna, Tenerife 38206, Spain.

Marina Porras (M)

Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Fco. Sánchez, 3, La Laguna, Tenerife 38206, Spain.

Alicia Boto (A)

Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Fco. Sánchez, 3, La Laguna, Tenerife 38206, Spain.

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Classifications MeSH