Atypical functional connectivity hierarchy in Rolandic epilepsy.


Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
10 07 2023
Historique:
received: 17 08 2022
accepted: 26 06 2023
medline: 12 7 2023
pubmed: 11 7 2023
entrez: 10 7 2023
Statut: epublish

Résumé

Functional connectivity hierarchy is an important principle in the process of brain functional organization and an important feature reflecting brain development. However, atypical brain network hierarchy organization in Rolandic epilepsy have not been systematically investigated. We examined connectivity alteration with age and its relation to epileptic incidence, cognition, or underlying genetic factors in 162 cases of Rolandic epilepsy and 117 typically developing children, by measuring fMRI multi-axis functional connectivity gradients. Rolandic epilepsy is characterized by contracting and slowing expansion of the functional connectivity gradients, highlighting the atypical age-related change of the connectivity hierarchy in segregation properties. The gradient alterations are relevant to seizure incidence, cognition, and connectivity deficit, and development-associated genetic basis. Collectively, our approach provides converging evidence for atypical connectivity hierarchy as a system-level substrate of Rolandic epilepsy, suggesting this is a disorder of information processing across multiple functional domains, and established a framework for large-scale brain hierarchical research.

Identifiants

pubmed: 37429897
doi: 10.1038/s42003-023-05075-8
pii: 10.1038/s42003-023-05075-8
pmc: PMC10333191
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

704

Informations de copyright

© 2023. The Author(s).

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Auteurs

Qirui Zhang (Q)

Department of Diagnostic Radiology, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, China.
Department of Diagnostic Radiology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China.

Jiao Li (J)

The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, 610054, China.

Yan He (Y)

Department of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, 210002, China.

Fang Yang (F)

Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China.

Qiang Xu (Q)

Department of Diagnostic Radiology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China.
College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 210002, China.

Sara Larivière (S)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, H3A 2B4, Canada.

Boris C Bernhardt (BC)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, H3A 2B4, Canada.

Wei Liao (W)

The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, 610054, China.

Guangming Lu (G)

Department of Diagnostic Radiology, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, China. cjr.luguangming@vip.163.com.
Department of Diagnostic Radiology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China. cjr.luguangming@vip.163.com.

Zhiqiang Zhang (Z)

Department of Diagnostic Radiology, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, China. zhangzq2001@126.com.
Department of Diagnostic Radiology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China. zhangzq2001@126.com.

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