Polyhedron-Like Biomaterials for Innervated and Vascularized Bone Regeneration.
3D printing
bone regeneration
innervation
polyhedron-like scaffolds
vascularization
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
revised:
16
06
2023
received:
23
03
2023
medline:
23
10
2023
pubmed:
12
7
2023
entrez:
12
7
2023
Statut:
ppublish
Résumé
Neural-vascular networks are densely distributed through periosteum, cortical bone, and cancellous bone, which is of great significance for bone regeneration and remodeling. Although significant progress has been made in bone tissue engineering, ineffective bone regeneration, and delayed osteointegration still remains an issue due to the ignorance of intrabony nerves and blood vessels. Herein, inspired by space-filling polyhedra with open architectures, polyhedron-like scaffolds with spatial topologies are prepared via 3D-printing technology to mimic the meshwork structure of cancellous bone. Benefiting from its spatial topologies, polyhedron-like scaffolds greatly promoted the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) via activating PI3K-Akt signals, and exhibiting satisfactory performance on angiogenesis and neurogenesis. Computational fluid dynamic (CFD) simulation elucidates that polyhedron-like scaffolds have a relatively lower area-weighted average static pressure, which is beneficial to osteogenesis. Furthermore, in vivo experiments further demonstrate that polyhedron-like scaffolds obviously promote bone formation and osteointegration, as well as inducing vascularization and ingrowth of nerves, leading to innervated and vascularized bone regeneration. Taken together, this work offers a promising approach for fabricating multifunctional scaffolds without additional exogenous seeding cells and growth factors, which holds great potential for functional tissue regeneration and further clinical translation.
Identifiants
pubmed: 37434296
doi: 10.1002/adma.202302716
doi:
Substances chimiques
Biocompatible Materials
0
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2302716Subventions
Organisme : National Key Research and Development Program of China
ID : 2021YFB3800800
Organisme : National Natural Science Foundation of China
ID : 32225028
Organisme : National Natural Science Foundation of China
ID : 32130062
Organisme : CAS Project for Young Scientists in Basic Research
ID : YSBR073
Organisme : Shanghai Pilot Program for Basic Research - Chinese Academy of Science
ID : JCYJ-SHFY-2022-003
Informations de copyright
© 2023 Wiley-VCH GmbH.
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