Brain volumes in alcohol use disorder: Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis.
MRI
alcohol dependence
alcohol use disorders
sex
voxel-based morphometry
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
03
02
2023
received:
26
07
2022
accepted:
09
06
2023
medline:
7
8
2023
pubmed:
12
7
2023
entrez:
12
7
2023
Statut:
ppublish
Résumé
Emerging evidence suggests distinct neurobiological correlates of alcohol use disorder (AUD) between sexes, which however remain largely unexplored. This work from ENIGMA Addiction Working Group aimed to characterize the sex differences in gray matter (GM) and white matter (WM) correlates of AUD using a whole-brain, voxel-based, multi-tissue mega-analytic approach, thereby extending our recent surface-based region of interest findings on a nearly matching sample using a complementary methodological approach. T1-weighted magnetic resonance imaging (MRI) data from 653 people with AUD and 326 controls was analyzed using voxel-based morphometry. The effects of group, sex, group-by-sex, and substance use severity in AUD on brain volumes were assessed using General Linear Models. Individuals with AUD relative to controls had lower GM volume in striatal, thalamic, cerebellar, and widespread cortical clusters. Group-by-sex effects were found in cerebellar GM and WM volumes, which were more affected by AUD in females than males. Smaller group-by-sex effects were also found in frontotemporal WM tracts, which were more affected in AUD females, and in temporo-occipital and midcingulate GM volumes, which were more affected in AUD males. AUD females but not males showed a negative association between monthly drinks and precentral GM volume. Our results suggest that AUD is associated with both shared and distinct widespread effects on GM and WM volumes in females and males. This evidence advances our previous region of interest knowledge, supporting the usefulness of adopting an exploratory perspective and the need to include sex as a relevant moderator variable in AUD.
Identifiants
pubmed: 37436103
doi: 10.1002/hbm.26404
pmc: PMC10400785
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4652-4666Informations de copyright
© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Références
Neuroimage Clin. 2021;30:102636
pubmed: 33857771
Cerebellum. 2015 Aug;14(4):421-37
pubmed: 25195804
Alcohol Clin Exp Res. 2011 Sep;35(9):1678-85
pubmed: 21599718
Clin Psychol Rev. 2020 Mar;76:101828
pubmed: 32062303
Neuroimage. 2007 Apr 1;35(2):787-94
pubmed: 17291784
Neuroimage Clin. 2015 Mar 20;8:39-50
pubmed: 26106526
Addict Biol. 2013 May;18(3):593-604
pubmed: 23240858
Neuropsychol Rev. 2010 Sep;20(3):280-9
pubmed: 20809198
Biol Psychiatry. 2014 Dec 15;76(12):963-9
pubmed: 24832866
Alcohol Clin Exp Res. 2013 Jan;37(1):110-22
pubmed: 22725728
Neuroimage. 2018 Feb 15;167:104-120
pubmed: 29155184
Alcohol Clin Exp Res. 2018 Oct;42(10):1939-1950
pubmed: 30080258
Alcohol Clin Exp Res. 2003 Feb;27(2):301-9
pubmed: 12605080
Neuroimage. 2002 Mar;15(3):708-18
pubmed: 11848714
Psychiatry Res. 2012 Nov 30;204(2-3):101-11
pubmed: 23149031
Neurosci Biobehav Rev. 2015 Jul;54:38-45
pubmed: 25108034
PLoS One. 2014 Jan 06;9(1):e84560
pubmed: 24400099
Neuropharmacology. 2017 Aug 1;122:175-188
pubmed: 28108358
Psychiatry Res. 2011 Dec 30;194(3):304-313
pubmed: 22047728
Neuroimage. 2009 Jan 1;44(1):99-111
pubmed: 18848632
Addict Biol. 2013 May;18(3):581-92
pubmed: 22458455
Hippocampus. 2010 May;20(5):596-607
pubmed: 19554644
Neuropsychol Rev. 2010 Mar;20(1):1-20
pubmed: 19685291
Drug Alcohol Depend. 2015 Nov 1;156:1-13
pubmed: 26371405
Biol Psychiatry. 2020 Apr 1;87(7):632-644
pubmed: 31653477
Psychiatry Investig. 2019 May;16(5):386-396
pubmed: 31132843
J Neurol Neurosurg Psychiatry. 2007 Jun;78(6):610-4
pubmed: 17088334
Am J Psychiatry. 2001 Feb;158(2):198-204
pubmed: 11156801
Biol Psychiatry. 2008 Aug 1;64(3):192-202
pubmed: 18374900
Cereb Cortex. 2018 Aug 1;28(8):2959-2975
pubmed: 29771288
Drug Alcohol Depend. 2015 Aug 1;153:22-8
pubmed: 26072220
Cereb Cortex. 2015 Nov;25(11):4155-68
pubmed: 24935777
Addiction. 2011 Nov;106(11):1935-43
pubmed: 21631621
Neurosci Biobehav Rev. 2023 Jan;144:104972
pubmed: 36436736
Psychiatry Res Neuroimaging. 2017 May 30;263:15-25
pubmed: 28285206
Neuroimage Clin. 2016 Nov 01;13:181-187
pubmed: 27981033
Arch Gen Psychiatry. 2001 Apr;58(4):345-52
pubmed: 11296095
Eur J Neurosci. 2009 Jun;29(11):2225-32
pubmed: 19490086
Biol Psychiatry. 2005 Apr 1;57(7):768-76
pubmed: 15820234
Am J Psychiatry. 2010 Aug;167(8):969-76
pubmed: 20439391
Pharmacol Biochem Behav. 2017 Jan;152:61-67
pubmed: 27498303
Neuropsychopharmacology. 2011 Nov;36(12):2513-28
pubmed: 21796110
Hum Brain Mapp. 2016 Jun;37(6):2276-92
pubmed: 26947584
Am J Psychiatry. 2001 Feb;158(2):188-97
pubmed: 11156800
Neuroimage. 2011 Feb 14;54(4):2582-9
pubmed: 20970506
Alcohol. 2010 Aug;44(5):439-45
pubmed: 20804943
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 1;44:51-7
pubmed: 23352887
Am J Drug Alcohol Abuse. 2013 Nov;39(6):345-55
pubmed: 24200204
Addict Behav. 2013 Feb;38(2):1532-1540
pubmed: 23148916
Biol Psychiatry. 2015 Aug 15;78(4):224-30
pubmed: 25861700
J Neurosci Res. 2021 Jan;99(1):309-323
pubmed: 32333417
Neurosci Biobehav Rev. 2016 Jul;66:92-103
pubmed: 27108216
Alcohol Clin Exp Res. 2013 Jun;37(6):896-904
pubmed: 23278386
Brain Connect. 2018 Oct;8(8):487-502
pubmed: 30198312
Transl Psychiatry. 2022 Jan 27;12(1):40
pubmed: 35087021
Ann Neurol. 2015 Jan;77(1):68-74
pubmed: 25377694
Alcohol Res. 2020 Sep 10;40(2):03
pubmed: 32923307
Transl Psychiatry. 2021 Mar 4;11(1):156
pubmed: 33664226
Hum Brain Mapp. 2023 Sep;44(13):4652-4666
pubmed: 37436103
Neurology. 2012 Apr 24;78(17):1330-3
pubmed: 22496200
Front Aging Neurosci. 2021 Feb 05;13:622054
pubmed: 33613268
Alcohol Clin Exp Res. 2016 Jun;40(6):1262-72
pubmed: 27130832
Front Neurol. 2019 Feb 12;10:98
pubmed: 30809188
Am J Psychiatry. 2019 Feb 1;176(2):119-128
pubmed: 30336705
Psychiatry Res. 2013 Oct 30;214(1):1-8
pubmed: 23916536
Alcohol Clin Exp Res. 2012 Feb;36(2):294-301
pubmed: 22085135
Neuropsychopharmacology. 2015 Jan;40(2):412-20
pubmed: 25079289
Alcohol Clin Exp Res. 2005 May;29(5):896-901
pubmed: 15897736
Biol Psychiatry. 2009 Apr 15;65(8):680-90
pubmed: 19103436
Neurobiol Stress. 2019 Feb 08;10:100149
pubmed: 30949562
Psychiatry Res. 2003 Jan 20;122(1):21-35
pubmed: 12589880