Amplifications of AURKA and AURKB in a Burkitt lymphoma immunodeficiency-associated type: a case report.
Journal
Einstein (Sao Paulo, Brazil)
ISSN: 2317-6385
Titre abrégé: Einstein (Sao Paulo)
Pays: Brazil
ID NLM: 101281800
Informations de publication
Date de publication:
2023
2023
Historique:
received:
04
11
2022
accepted:
19
03
2023
medline:
14
7
2023
pubmed:
12
7
2023
entrez:
12
7
2023
Statut:
epublish
Résumé
In equatorial Brazil, the association of Burkitt lymphoma and Epstein-Barr virus manifests at high rates. Here, we report, for the first time, amplifications of aurora kinase genes (AURKA/B) in a patient with a history of periodontal abscess and the presence of a remaining nodule, diagnosed with Burkitt lymphoma and Epstein-Barr virus, and /HIV positive. The patient was a 38-year-old man who presented with a 2-week-old severe jaw pain and a 3-day-old severe bilateral headache. He had a history of human papilloma virus. Interphase FISH analysis showed AURKA and AURKB amplification. The patient's condition worsened, progressing to death a month after the initial care. Changes in the MYCC and AURKA pathways are directly associated with genomic instability. Thus, MYCC rearrangements and higher expression of AURKA/B may be associated with therapy resistance, highlighting the importance of AURKA/B evaluation in Burkitt lymphoma.
Identifiants
pubmed: 37436268
pii: S1679-45082023000100507
doi: 10.31744/einstein_journal/2023RC0378
pmc: PMC10317141
pii:
doi:
Substances chimiques
Aurora Kinase A
EC 2.7.11.1
Aurora Kinase B
EC 2.7.11.1
AURKB protein, human
EC 2.7.11.1
AURKA protein, human
EC 2.7.11.1
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
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