Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
13 07 2023
13 07 2023
Historique:
received:
07
11
2022
accepted:
04
07
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
13
7
2023
Statut:
epublish
Résumé
GWAS have identified numerous genes associated with human cognition but their cell type expression profiles in the human brain are unknown. These genes overlap with human accelerated regions (HARs) implicated in human brain evolution and might act on the same biological processes. Here, we investigated whether these gene sets are expressed in adult human cortical neurons, and how their expression relates to neuronal function and structure. We find that these gene sets are preferentially expressed in L3 pyramidal neurons in middle temporal gyrus (MTG). Furthermore, neurons with higher expression had larger total dendritic length (TDL) and faster action potential (AP) kinetics, properties previously linked to intelligence. We identify a subset of genes associated with TDL or AP kinetics with predominantly synaptic functions and high abundance of HARs.
Identifiants
pubmed: 37443107
doi: 10.1038/s41467-023-39946-9
pii: 10.1038/s41467-023-39946-9
pmc: PMC10345092
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4188Subventions
Organisme : European Research Council
ID : 101093198
Pays : International
Organisme : NIMH NIH HHS
ID : U01 MH114812
Pays : United States
Organisme : NIMH NIH HHS
ID : UM1 MH130981
Pays : United States
Informations de copyright
© 2023. The Author(s).
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