Thiophosphate photochemistry enables prebiotic access to sugars and terpenoid precursors.
Journal
Nature chemistry
ISSN: 1755-4349
Titre abrégé: Nat Chem
Pays: England
ID NLM: 101499734
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
01
11
2019
accepted:
22
05
2023
medline:
29
9
2023
pubmed:
14
7
2023
entrez:
13
7
2023
Statut:
ppublish
Résumé
Over the past few years, evidence has accrued that demonstrates that terrestrial photochemical reactions could have provided numerous (proto)biomolecules with implications for the origin of life. This chemistry simply relies on UV light, inorganic sulfur species and hydrogen cyanide. Recently, we reported that, under the same conditions, reduced phosphorus species, such as those delivered by meteorites, can be oxidized to orthophosphate, generating thiophosphate in the process. Here we describe an investigation of the properties of thiophosphate as well as additional possible means for its formation on primitive Earth. We show that several reported prebiotic reactions, including the photoreduction of thioamides, carbonyl groups and cyanohydrins, can be markedly improved, and that tetroses and pentoses can be accessed from hydrogen cyanide through a Kiliani-Fischer-type process without progressing to higher sugars. We also demonstrate that thiophosphate allows photochemical reductive aminations, and that thiophosphate chemistry allows a plausible prebiotic synthesis of the C
Identifiants
pubmed: 37443293
doi: 10.1038/s41557-023-01251-9
pii: 10.1038/s41557-023-01251-9
pmc: PMC10533393
mid: EMS176196
doi:
Substances chimiques
thiophosphoric acid
TYM4M7EWCW
Sugars
0
Hydrogen Cyanide
2WTB3V159F
Terpenes
0
Phosphates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1470-1477Subventions
Organisme : Medical Research Council
ID : MC_UP_A024_1009
Pays : United Kingdom
Informations de copyright
© 2023. The Author(s).
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