Activation/Inhibition of Cholinesterases by Excess Substrate: Interpretation of the Phenomenological

acetylcholinesterase b factor butyrylcholinesterase competing substrate kinetics excess substrate activation/inhibition

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
21 Jun 2023
Historique:
received: 03 06 2023
revised: 19 06 2023
accepted: 19 06 2023
medline: 17 7 2023
pubmed: 14 7 2023
entrez: 14 7 2023
Statut: epublish

Résumé

Cholinesterases (ChEs) display a non-michaelian behavior with positively charged substrates. In the steady-state rate equation, the b factor describes this behavior: if

Identifiants

pubmed: 37445649
pii: ijms241310472
doi: 10.3390/ijms241310472
pmc: PMC10341919
pii:
doi:

Substances chimiques

Cholinesterases EC 3.1.1.8
Esters 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Kazan Federal University

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Auteurs

Aliya R Mukhametgalieva (AR)

Biochemical Neuropharmacology Laboratory, Kazan Federal University, 18 Ul. Kremlevskaya, 420008 Kazan, Russia.

Andrey V Nemtarev (AV)

Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 8 Ul. Arbuzov, 420088 Kazan, Russia.

Viktor V Sykaev (VV)

Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 8 Ul. Arbuzov, 420088 Kazan, Russia.

Tatiana N Pashirova (TN)

Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 8 Ul. Arbuzov, 420088 Kazan, Russia.

Patrick Masson (P)

Biochemical Neuropharmacology Laboratory, Kazan Federal University, 18 Ul. Kremlevskaya, 420008 Kazan, Russia.

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Classifications MeSH