Microchimerism as Post-Transplant Marker of a Chronic Rejection Process.
microchimerism
rejection
renal transplantation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Jun 2023
25 Jun 2023
Historique:
received:
14
05
2023
revised:
15
06
2023
accepted:
19
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
The risk of losing a transplanted organ is high, and non-invasive markers to warn of this phenomenon are still being sought. We investigated the impact of post-transplant microchimerism on the function of the transplanted kidney. The study included 100 kidney transplant recipients, mostly women. All transplanted organs were from opposite-sex deceased donors. Microchimerism was assessed using multiplex PCR. Male DNA was detected in all urine samples from female recipients and in 13/56 blood samples from female kidney recipients. Female DNA was found in 31/44 urine samples from male recipients, but in none of the blood samples. Microchimerism in the urine of female recipients correlated positively with blood urea (Rs = 0.45;
Identifiants
pubmed: 37445781
pii: ijms241310603
doi: 10.3390/ijms241310603
pmc: PMC10341469
pii:
doi:
Substances chimiques
DNA
9007-49-2
Urea
8W8T17847W
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Higher Education
ID : N N403 143939
Références
Eur Heart J. 2018 May 1;39(17):1535-1542
pubmed: 29554312
Arthritis Rheum. 2004 Mar;50(3):906-14
pubmed: 15022334
Pediatr Nephrol. 2021 Jan;36(1):31-40
pubmed: 31820146
Transpl Int. 2002 Jan;15(1):10-6
pubmed: 11875607
Transfusion. 2001 Dec;41(12):1524-30
pubmed: 11778067
Lupus. 2002;11(10):651-4
pubmed: 12413060
Ann Transplant. 2018 Dec 21;23:874-878
pubmed: 30573723
Lancet. 1994 Jun 11;343(8911):1468-9
pubmed: 7911179
Transplantation. 2007 Nov 15;84(9):1103-11
pubmed: 17998864
N Am J Med Sci. 2010 Apr;2(4):170-3
pubmed: 22624135
Transpl Immunol. 2012 Mar;26(2-3):151-5
pubmed: 22108535
Front Immunol. 2022 Jan 05;12:791725
pubmed: 35069574
Clin Chem. 2006 Mar;52(3):379-82
pubmed: 16397013
Int J Dev Biol. 2010;54(2-3):531-43
pubmed: 19924635
Urol Int. 2020;104(11-12):865-870
pubmed: 32957110
Ann Transplant. 2013 Feb 25;18:76-81
pubmed: 23792505
Transplant Direct. 2017 Apr 07;3(5):e152
pubmed: 28573187
Transplantation. 2019 Feb;103(2):273-283
pubmed: 30308576
Bioessays. 2015 Oct;37(10):1106-18
pubmed: 26316378
BMC Nephrol. 2018 May 18;19(1):116
pubmed: 29776389
Transpl Int. 2000;13 Suppl 1:S95-8
pubmed: 11111972
Postepy Hig Med Dosw (Online). 2006;60:163-9
pubmed: 16552396
Transplantation. 2001 Aug 27;72(4):674-8
pubmed: 11544430
N Engl J Med. 2021 Aug 19;385(8):729-743
pubmed: 34407344
Nat Rev Nephrol. 2018 Mar;14(3):203-210
pubmed: 29380816
Blood. 1995 Mar 1;85(5):1207-14
pubmed: 7858251
Front Immunol. 2021 May 20;12:661643
pubmed: 34093552
Hum Reprod. 2003 Sep;18(9):1933-6
pubmed: 12923152
Chin Med J (Engl). 2007 May 20;120(10):859-62
pubmed: 17543173
Clin Nephrol. 2001 Apr;55(4):309-12
pubmed: 11334317
Clin Genet. 2001 Aug;60(2):145-50
pubmed: 11553049
Clin Chem. 2000 Aug;46(8 Pt 1):1078-84
pubmed: 10926886
Afr Health Sci. 2014 Dec;14(4):1025-35
pubmed: 25834515
Int J Immunogenet. 2020 Dec;47(6):494-500
pubmed: 32881306
Lancet. 2004 Jul 10-16;364(9429):179-82
pubmed: 15246731
Semin Hematol. 2007 Jan;44(1):24-31
pubmed: 17198844
Lancet. 1998 May 2;351(9112):1329-30
pubmed: 9643800
Chimerism. 2010 Oct;1(2):66-8
pubmed: 21327051
Transplant Proc. 2018 Jul - Aug;50(6):1738-1743
pubmed: 30056892
Transplantation. 1995 Jan 27;59(2):191-6
pubmed: 7839440
PLoS One. 2012;7(9):e45592
pubmed: 23049819
Clin Chem. 1999 Oct;45(10):1741-6
pubmed: 10508119
Blood Cells Mol Dis. 2003 Jan-Feb;30(1):13-21
pubmed: 12667983
Transplant Proc. 2008 Dec;40(10):3434-6
pubmed: 19100406
N Engl J Med. 1994 Mar 3;330(9):646-7
pubmed: 8302359
Clin Transpl. 2001;:1-18
pubmed: 12211771
Am J Med. 2005 Aug;118(8):899-906
pubmed: 16084184
Blood. 1999 May 1;93(9):3127-39
pubmed: 10216112