ECM Composition Differentially Regulates Intracellular and Extracellular pH in Normal and Cancer Pancreatic Duct Epithelial Cells.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
25 Jun 2023
Historique:
received: 07 04 2023
revised: 07 06 2023
accepted: 17 06 2023
medline: 17 7 2023
pubmed: 14 7 2023
entrez: 14 7 2023
Statut: epublish

Résumé

Intracellular pH (pHi) regulation is a challenge for the exocrine pancreas, where the luminal secretion of bicarbonate-rich fluid is accompanied by interstitial flows of acid. This acid-base transport requires a plethora of ion transporters, including bicarbonate transporters and the Na

Identifiants

pubmed: 37445810
pii: ijms241310632
doi: 10.3390/ijms241310632
pmc: PMC10341693
pii:
doi:

Substances chimiques

Bicarbonates 0
Collagen Type I 0
Sodium-Hydrogen Exchangers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Marie Curie
ID : 813834; H2020-446 MSCA-ITN-2018
Pays : United Kingdom

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Auteurs

Daria Di Molfetta (D)

Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70126 Bari, Italy.

Stefania Cannone (S)

Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70126 Bari, Italy.

Maria Raffaella Greco (MR)

Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70126 Bari, Italy.

Rosa Caroppo (R)

Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70126 Bari, Italy.

Francesca Piccapane (F)

Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70126 Bari, Italy.

Tiago Miguel Amaral Carvalho (TMA)

Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70126 Bari, Italy.

Concetta Altamura (C)

Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.

Ilaria Saltarella (I)

Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.

Diana Tavares Valente (D)

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.

Jean Francois Desaphy (JF)

Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.

Stephan J Reshkin (SJ)

Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70126 Bari, Italy.

Rosa Angela Cardone (RA)

Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70126 Bari, Italy.

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Classifications MeSH