Targeting Opioid Receptors in Addiction and Drug Withdrawal: Where Are We Going?
drug addiction
drug withdrawal
opioid receptors
opioid use disorder (OUD)
opioids
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Jun 2023
29 Jun 2023
Historique:
received:
29
04
2023
revised:
14
06
2023
accepted:
28
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
This review article offers an outlook on the use of opioids as therapeutics for treating several diseases, including cancer and non-cancer pain, and focuses the analysis on the opportunity to target opioid receptors for treating opioid use disorder (OUD), drug withdrawal, and addiction. Unfortunately, as has been well established, the use of opioids presents a plethora of side effects, such as tolerance and physical and physiological dependence. Accordingly, considering the great pharmacological potential in targeting opioid receptors, the identification of opioid receptor ligands devoid of most of the adverse effects exhibited by current therapeutic agents is highly necessary. To this end, herein, we analyze some interesting molecules that could potentially be useful for treating OUD, with an in-depth analysis regarding in vivo studies and clinical trials.
Identifiants
pubmed: 37446064
pii: ijms241310888
doi: 10.3390/ijms241310888
pmc: PMC10341731
pii:
doi:
Substances chimiques
Analgesics, Opioid
0
Receptors, Opioid
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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