Motifs in Natural Products as Useful Scaffolds to Obtain Novel Benzo[
CB2 agonists
benzimidazoles
cannabinoid receptor
natural products
synthesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Jun 2023
30 Jun 2023
Historique:
received:
24
03
2023
revised:
02
05
2023
accepted:
11
05
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
The endocannabinoid system (ECS) constitutes a broad-spectrum modulator of homeostasis in mammals, providing therapeutic opportunities for several pathologies. Its two main receptors, cannabinoid type 1 (CB1) and type 2 (CB2) receptors, mediate anti-inflammatory responses; however, their differing patterns of expression make the development of CB2-selective ligands therapeutically more attractive. The benzo[
Identifiants
pubmed: 37446093
pii: ijms241310918
doi: 10.3390/ijms241310918
pmc: PMC10341893
pii:
doi:
Substances chimiques
Cannabinoid Receptor Agonists
0
imidazole
7GBN705NH1
Biological Products
0
Cannabinoids
0
Imidazoles
0
Receptor, Cannabinoid, CB2
0
Receptor, Cannabinoid, CB1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agencia Nacional de Investigación y Desarrollo
ID : 1150121
Organisme : Agencia Nacional de Investigación y Desarrollo
ID : 11190145
Références
J Med Chem. 2020 Jul 9;63(13):7369-7391
pubmed: 32515588
Biol Psychiatry. 2016 Apr 1;79(7):516-25
pubmed: 26698193
Nature. 1993 Sep 2;365(6441):61-5
pubmed: 7689702
Arch Pharm (Weinheim). 2015 Feb;348(2):81-8
pubmed: 25641513
Mol Pharmacol. 2014 Oct;86(4):430-7
pubmed: 25106425
BMC Chem. 2019 Aug 6;13(1):101
pubmed: 31410412
Nat Protoc. 2008;3(7):1125-31
pubmed: 18600217
Eur J Med Chem. 2016 Nov 29;124:17-35
pubmed: 27560280
Int J Mol Sci. 2021 Aug 31;22(17):
pubmed: 34502379
Cell. 2020 Feb 20;180(4):645-654.e13
pubmed: 32004460
Curr Pharm Des. 2016;22(12):1756-66
pubmed: 26654588
Antioxidants (Basel). 2020 Nov 27;9(12):
pubmed: 33260980
J Neuroendocrinol. 2008 May;20 Suppl 1:10-4
pubmed: 18426493
Int J Mol Sci. 2021 Oct 18;22(20):
pubmed: 34681877
Molecules. 2014 Mar 05;19(3):2842-61
pubmed: 24603555
Bioorg Med Chem. 2012 Nov 1;20(21):6208-36
pubmed: 23031649
Int J Mol Sci. 2020 Jul 17;21(14):
pubmed: 32709050
Mol Pharmacol. 1995 Sep;48(3):443-50
pubmed: 7565624
J Cannabis Res. 2020 May 11;2(1):17
pubmed: 33526117
Handb Exp Pharmacol. 2015;231:1-37
pubmed: 26408156
Br J Pharmacol. 2011 Aug;163(7):1344-64
pubmed: 21749363
Int J Mol Sci. 2019 May 21;20(10):
pubmed: 31117309
Arch Pharm (Weinheim). 2016 Jul;349(7):475-506
pubmed: 27213292
Nucleic Acids Res. 2021 Jul 2;49(W1):W530-W534
pubmed: 33950214
J Nat Prod. 2011 Mar 25;74(3):496-511
pubmed: 21138324
Chem Biol Drug Des. 2015 Jul;86(1):19-65
pubmed: 25352112
Nat Rev Drug Discov. 2005 Mar;4(3):206-20
pubmed: 15729362
Front Pharmacol. 2021 Aug 13;12:704197
pubmed: 34483907
Front Pharmacol. 2021 Jul 30;12:702675
pubmed: 34393784
Eur J Pharm Sci. 2017 Apr 1;101:1-10
pubmed: 28137469