Immunomodulation Therapies for Atherosclerosis: The Past, the Present, and the Future.
atherosclerosis
cardiovascular disease
immune-modulation therapies
inflammation
vaccine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
01 Jul 2023
01 Jul 2023
Historique:
received:
28
05
2023
revised:
26
06
2023
accepted:
30
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Atherosclerotic cardiovascular disease is the most common cause of morbidity and death worldwide. Recent studies have demonstrated that this chronic inflammatory disease of the arterial wall can be controlled through the modulation of immune system activity. Many patients with cardiovascular disease remain at elevated risk of recurrent events despite receiving current, state-of-the-art preventive medical treatment. Much of this residual risk is attributed to inflammation. Therefore, finding new treatment strategies for this category of patients became of common interest. This review will discuss the experimental and clinical data supporting the possibility of developing immune-based therapies for lowering cardiovascular risk, explicitly focusing on vaccination strategies.
Identifiants
pubmed: 37446157
pii: ijms241310979
doi: 10.3390/ijms241310979
pmc: PMC10342012
pii:
doi:
Substances chimiques
Autoantigens
0
Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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