Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models.
atherosclerosis
eicosanoids
fatty acids
inflammation
lipids
metabolism
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Jul 2023
03 Jul 2023
Historique:
received:
05
05
2023
revised:
28
06
2023
accepted:
29
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in the pathogenesis of inflammatory diseases, and its pro- and anti-inflammatory effects have been reported for different ALOX-isoforms. Human ALOX15B oxygenates arachidonic acid to its 15-hydroperoxy derivative, whereas the corresponding 8-hydroperoxide is formed by mouse Alox15b (Alox8). This functional difference impacts the biosynthetic capacity of the two enzymes for creating pro- and anti-inflammatory eicosanoids. To explore the functional consequences of the humanization of the reaction specificity of mouse
Identifiants
pubmed: 37446212
pii: ijms241311034
doi: 10.3390/ijms241311034
pmc: PMC10341735
pii:
doi:
Substances chimiques
Arachidonic Acid
27YG812J1I
sodium sulfate
0YPR65R21J
Dextrans
0
Anti-Inflammatory Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : HE8295/1-1
Organisme : Deutsche Forschungsgemeinschaft
ID : KU961/13-1
Organisme : Deutsche Forschungsgemeinschaft
ID : KU961/14-1
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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