Molecular Taphonomy of Heme: Chemical Degradation of Hemin under Presumed Fossilization Conditions.
dinosaurs
fossilization
hematinic acid
heme
mass spectrometry
molecular taphonomy
oxidation
paleontology
porphyrin
preservation
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
21 Jun 2023
21 Jun 2023
Historique:
received:
26
05
2023
revised:
16
06
2023
accepted:
18
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
The metalloporphyrin heme acts as the oxygen-complexing prosthetic group of hemoglobin in blood. Heme has been noted to survive for many millions of years in fossils. Here, we investigate its stability and degradation under various conditions expected to occur during fossilization. Oxidative, reductive, aerobic, and anaerobic conditions were studied at neutral and alkaline pH values. Elevated temperatures were applied to accelerate degradation. High-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) identified four main degradation products. The vinyl residues are oxidized to formyl and further to carboxylate groups. In the presence of air or H
Identifiants
pubmed: 37446548
pii: molecules28134887
doi: 10.3390/molecules28134887
pmc: PMC10343206
pii:
doi:
Substances chimiques
Heme
42VZT0U6YR
Hemin
743LRP9S7N
Hydrogen Peroxide
BBX060AN9V
Iron
E1UOL152H7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : MU 1665/8-1 and 8-2; EN 711/2-1 and 3-1; SA 469/54-1 and 54-2
Organisme : Deutsche Forschungsgemeinschaft
ID : FOR 2685 The Limits of the Fossil Record: Analytical and Experimental Approaches to Fossilization
Références
Chemistry. 2020 May 15;26(28):6205-6213
pubmed: 31971638
Crit Rev Biochem Mol Biol. 1995;30(3):165-96
pubmed: 7555018
J Biol Chem. 1998 Jan 9;273(2):837-41
pubmed: 9422739
J Inorg Biochem. 2016 Jan;154:103-13
pubmed: 26598215
Biology (Basel). 2022 Apr 27;11(5):
pubmed: 35625398
Proc Biol Sci. 2013 Nov 27;281(1775):20132741
pubmed: 24285202
Philos Trans R Soc Lond B Biol Sci. 1991 Sep 30;333(1268):315-27; discussion 327-8
pubmed: 1684047
FEBS Lett. 1993 Oct 18;332(3):287-90
pubmed: 8405472
Pediatr Res. 1984 Aug;18(8):696-700
pubmed: 6472940
Environ Sci Technol. 2008 Sep 1;42(17):6526-31
pubmed: 18800525
Trends Plant Sci. 2003 Aug;8(8):387-93
pubmed: 12927972
J Chem Soc Perkin 1. 1973;9:881-8
pubmed: 4735584
Proc Natl Acad Sci U S A. 1968 Oct;61(2):748-55
pubmed: 4386763
Inorg Chem. 2011 Aug 1;50(15):6922-8
pubmed: 21714484
Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6291-6
pubmed: 9177210
J Bacteriol. 1997 Feb;179(3):838-45
pubmed: 9006041
Angew Chem Int Ed Engl. 1970 Jul;9(7):473-80
pubmed: 4988144
J Bacteriol. 2000 Dec;182(23):6783-90
pubmed: 11073924
Biochem Biophys Res Commun. 2005 Dec 9;338(1):558-67
pubmed: 16115609
Sci Rep. 2017 Oct 17;7(1):13324
pubmed: 29042651
Biochemistry. 1985 Jun 18;24(13):3254-63
pubmed: 3927975
Biochemistry. 1978 Aug 22;17(17):3633-9
pubmed: 28754
PeerJ. 2017 Aug 29;5:e3706
pubmed: 28875070
Proc Biol Sci. 2007 Jan 22;274(1607):183-97
pubmed: 17148248
RSC Adv. 2021 Feb 17;11(13):7552-7563
pubmed: 35423242
Biol Pharm Bull. 1994 Jun;17(6):856-8
pubmed: 7951155
J Bacteriol. 2001 Nov;183(21):6394-403
pubmed: 11591684
Biochem Soc Trans. 2002 Aug;30(4):604-9
pubmed: 12196146
J Bacteriol. 2000 Jan;182(2):439-47
pubmed: 10629191
Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18496-500
pubmed: 24127577
Nature. 1958 Aug 2;182(4631):316
pubmed: 13577824
Biochemistry. 1980 Jan 22;19(2):379-85
pubmed: 7352992
Adv Ther. 2008 Sep;25(9):842-57
pubmed: 18777015
FEBS Lett. 1972 Sep 1;25(1):94-96
pubmed: 11946729
Forensic Sci Res. 2018 Oct 08;4(1):51-59
pubmed: 30915417
Arch Biochem Biophys. 1960 Oct;90:229-33
pubmed: 13743904
Biochem J. 1950 Jun-Jul;47(1):97-104
pubmed: 14791314
Nature. 1958 Dec 13;182(4650):1671-2
pubmed: 13622612
J Inorg Biochem. 2000 Nov;82(1-4):33-41
pubmed: 11132636
Biochemistry. 1974 Oct 8;13(21):4386-94
pubmed: 4415726
J Am Chem Soc. 2015 Jul 1;137(25):8206-18
pubmed: 26027938
J Biol Chem. 2004 Jan 30;279(5):3426-33
pubmed: 14615478
J Chem Soc Perkin 1. 1974;4:480-90
pubmed: 4856318