Evaluation of Antimicrobial, Anticholinesterase Potential of Indole Derivatives and Unexpectedly Synthesized Novel Benzodiazine: Characterization, DFT and Hirshfeld Charge Analysis.

Cholinesterase Inhibitors / pharmacology Anti-Infective Agents Indoles / chemistry Anti-Bacterial Agents / pharmacology Antipsychotic Agents Benzodiazepines
DFT anticholinesterase antimicrobial benzodiazine indole novel benzodiazine

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
27 Jun 2023
Historique:
received: 13 05 2023
revised: 07 06 2023
accepted: 15 06 2023
medline: 17 7 2023
pubmed: 14 7 2023
entrez: 14 7 2023
Statut: epublish

Résumé

The pharmacological effectiveness of indoles, benzoxazepines and benzodiazepines initiated our synthesis of indole fused benoxazepine/benzodiazepine heterocycles, along with enhanced biological usefulness of the fused rings. Activated indoles

Identifiants

DOI: 10.3390/molecules28135024 PMID: 37446687 PMC: PMC10343724
pubmed: 37446687
pii: molecules28135024
doi: 10.3390/molecules28135024
pmc: PMC10343724
pii:
doi:

Substances chimiques

Cholinesterase Inhibitors 0
Anti-Infective Agents 0
Indoles 0
Anti-Bacterial Agents 0
Antipsychotic Agents 0
Benzodiazepines 12794-10-4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Abdul Rauf Raza (AR)

Institute of Chemistry, Ibn e Sina Block, University of Sargodha, Sargodha 40100, Pakistan.
ORCID: 0000-0002-4053-4862

Syeda Laila Rubab (SL)

Department of Chemistry, Division of Science and Technology, University of Education, Lahore 54770, Pakistan.

Muhammad Ashfaq (M)

Department of Physics, University of Sargodha, Sargodha 40100, Pakistan.
ORCID: 0000-0001-6663-8777

Yasir Altaf (Y)

Department of Chemistry, Division of Science and Technology, University of Education, Lahore 54770, Pakistan.
School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington 6140, New Zealand.

Muhammad Nawaz Tahir (MN)

Department of Physics, University of Sargodha, Sargodha 40100, Pakistan.

Muhammad Fayyaz Ur Rehman (MFU)

Institute of Chemistry, Ibn e Sina Block, University of Sargodha, Sargodha 40100, Pakistan.
ORCID: 0000-0003-2901-7212

Tariq Aziz (T)

Department of Agriculture, University of Ioannina, 471 32 Arta, Greece.
ORCID: 0000-0003-0905-8076

Metab Alharbi (M)

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.

Abdullah F Alasmari (AF)

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
ORCID: 0000-0001-7569-4287

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Evaluation of Antimicrobial,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Evaluation of Antimicrobial,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Evaluation of Antimicrobial,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Evaluation of Antimicrobial,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Tranquillisants › Neuroleptiques › Evaluation of Antimicrobial,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Evaluation of Antimicrobial,...