Cabazitaxel prodrug nanoassemblies with branched chain modifications: Narrowing the gap between efficacy and safety.

Prodrugs Nanoparticles Drug Delivery Systems Taxoids Cell Line, Tumor
Branched chain aliphatic alcohols Cabazitaxel Disulfide bond Prodrug nanoassemblies Toxicity-reducing and efficacy-enhancing

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
08 2023
Historique:
received: 10 05 2023
revised: 29 06 2023
accepted: 07 07 2023
medline: 21 8 2023
pubmed: 15 7 2023
entrez: 14 7 2023
Statut: ppublish

Résumé

The clinical application of cabazitaxel (CTX) is restricted by severe dose-related toxicity, failing to considering therapeutic efficacy and safety together. Self-assembled prodrugs promote new drug delivery paradigms as they can self-deliver and self-formulate. However, the current studies mainly focused on the use of straight chains to construct self-assembled prodrugs, and the role of branched chains in prodrug nanoassemblies remains to be clarified. In this study, we systematically explored the structure-function relationship of prodrug nanoassemblies using four CTX prodrugs that contained branched chain aliphatic alcohols (BAs) with different alkyl lengths. Overall, CTX-SS-BA

Identifiants

DOI: 10.1016/j.jconrel.2023.07.012 PMID: 37451544
pubmed: 37451544
pii: S0168-3659(23)00436-4
doi: 10.1016/j.jconrel.2023.07.012
pii:
doi:

Substances chimiques

Prodrugs 0
cabazitaxel 51F690397J
Taxoids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

784-795

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflict of interest.

Auteurs

Hezhen Xu (H)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

Shiyi Zuo (S)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

Danping Wang (D)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

Yu Zhang (Y)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

Wenxiao Li (W)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

Lingxiao Li (L)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

Tian Liu (T)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

Yuanhao Yu (Y)

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.

Qingzhi Lv (Q)

School of Pharmacy, Binzhou Medical University, Binzhou 256603, China.

Zhonggui He (Z)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

Jin Sun (J)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: sunjin@syphu.edu.cn.

Bingjun Sun (B)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: sunbingjun_spy@sina.com.

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Classifications MeSH

questionsmedicales.fr › Préparations pharmaceutiques › Promédicaments › Cabazitaxel prodrug nanoassemblies with...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Cabazitaxel prodrug nanoassemblies with...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Cabazitaxel prodrug nanoassemblies with...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Taxoïdes › Cabazitaxel prodrug nanoassemblies with...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cabazitaxel prodrug nanoassemblies with...