Photoinduced bidirectional switching in lipid membranes containing azobenzene glycolipids.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 Jul 2023
16 Jul 2023
Historique:
received:
02
11
2022
accepted:
06
07
2023
medline:
17
7
2023
pubmed:
17
7
2023
entrez:
16
7
2023
Statut:
epublish
Résumé
Following the reaction of biological membranes to external stimuli reveals fundamental insights into cellular function. Here, self-assembled lipid monolayers act as model membranes containing photoswitchable azobenzene glycolipids for investigating structural response during isomerization by combining Langmuir isotherms with X-ray scattering. Controlled in-situ trans/cis photoswitching of the azobenzene N = N double bond alters the DPPC monolayer structure, causing reproducible changes in surface pressure and layer thickness, indicating monolayer reorientation. Interestingly, for monolayers containing azobenzene glycolipids, along with the expected DPPC phase transitions an additional discontinuity is observed. The associated reorintation represents a crossover point, with the surface pressure and layer thickness changing in opposite directions above and below. This is evidence that the azobenzene glycolipids themselves change orientation within the monolayer. Such behaviour suggests that azobenzene glycolipids can act as a bidirectional switch in DPPC monolayers providing a tool to investigate membrane structure-function relationships in depth.
Identifiants
pubmed: 37455299
doi: 10.1038/s41598-023-38336-x
pii: 10.1038/s41598-023-38336-x
pmc: PMC10350456
doi:
Substances chimiques
Azo Compounds
0
azobenzene
F0U1H6UG5C
Glycolipids
0
Membrane Lipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11480Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB677
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB677
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB677
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB677
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB677
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB677
Organisme : Bundesministerium für Bildung und Forschung
ID : 05K19FK2
Organisme : Bundesministerium für Bildung und Forschung
ID : 05K19FK2
Organisme : Bundesministerium für Bildung und Forschung
ID : 05K19FK2
Organisme : Deutsches Elektronen-Synchrotron
ID : CMWS - Startup grant
Informations de copyright
© 2023. The Author(s).
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