BAFFR expression in circulating T follicular helper (CD4
BAFFR
IL-21
SLEDAI-2K
T peripheral helper (Tph) cells
circulating T follicular helper (cTfh) cells
systemic lupus erythematosus
Journal
Lupus
ISSN: 1477-0962
Titre abrégé: Lupus
Pays: England
ID NLM: 9204265
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
medline:
8
8
2023
pubmed:
18
7
2023
entrez:
17
7
2023
Statut:
ppublish
Résumé
Circulating T follicular helper (cTfh) and T peripheral helper (Tph) subpopulations are shown to be higher in systemic lupus erythematosus (SLE) patients and have been involved in promoting extrafollicular B cell responses. However, a possible association with the B cell activating factor (BAFF), a cytokine mainly related to B cell responses and disease activity in SLE, has not been investigated. Therefore, this study aimed to evaluate the association of cTfh and Tph subpopulations with the BAFF system expression and clinical activity in SLE patients. This study included 43 SLE patients and 12 healthy subjects (HS). The identification of cTfh (CD4 Compared with HS, SLE patients showed a significantly increased percentage of cTfh and Tph cells, higher in patients with clearly active disease. SLE patients had markedly higher IL-21-producing cTfh and Tph cells than HS. Both subpopulations were positively correlated with the disease activity in SLE patients. Tph cells were negatively correlated with CD19 This study emphasizes the importance of cTfh and Tph cells in SLE pathogenesis. Besides the importance of IL-21, our results suggest that BAFFR could play a role in cTfh and Tph subpopulations in the autoimmunity context.
Sections du résumé
BACKGROUND
BACKGROUND
Circulating T follicular helper (cTfh) and T peripheral helper (Tph) subpopulations are shown to be higher in systemic lupus erythematosus (SLE) patients and have been involved in promoting extrafollicular B cell responses. However, a possible association with the B cell activating factor (BAFF), a cytokine mainly related to B cell responses and disease activity in SLE, has not been investigated. Therefore, this study aimed to evaluate the association of cTfh and Tph subpopulations with the BAFF system expression and clinical activity in SLE patients.
METHODS
METHODS
This study included 43 SLE patients and 12 healthy subjects (HS). The identification of cTfh (CD4
RESULTS
RESULTS
Compared with HS, SLE patients showed a significantly increased percentage of cTfh and Tph cells, higher in patients with clearly active disease. SLE patients had markedly higher IL-21-producing cTfh and Tph cells than HS. Both subpopulations were positively correlated with the disease activity in SLE patients. Tph cells were negatively correlated with CD19
CONCLUSIONS
CONCLUSIONS
This study emphasizes the importance of cTfh and Tph cells in SLE pathogenesis. Besides the importance of IL-21, our results suggest that BAFFR could play a role in cTfh and Tph subpopulations in the autoimmunity context.
Identifiants
pubmed: 37460408
doi: 10.1177/09612033231189804
doi:
Substances chimiques
B-Cell Maturation Antigen
0
CXCR5 protein, human
0
Programmed Cell Death 1 Receptor
0
Receptors, CXCR5
0
TNFRSF13C protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM