Organometallic Ru, Os, Rh and Ir half-sandwich conjugates of ispinesib - impact of the organometallic group on the antimitotic activity.

Antimitotic Agents / pharmacology Reactive Oxygen Species Quinazolines Benzamides / metabolism Antineoplastic Agents Organometallic Compounds / pharmacology

Journal

Dalton transactions (Cambridge, England : 2003)
ISSN: 1477-9234
Titre abrégé: Dalton Trans
Pays: England
ID NLM: 101176026

Informations de publication

Date de publication:
29 Aug 2023
Historique:
medline: 31 8 2023
pubmed: 19 7 2023
entrez: 19 7 2023
Statut: epublish

Résumé

Antimitotic agents are among the most important drugs used in anticancer therapy. Kinesin spindle protein (KSP) was proposed as a promising target for new antimitotic drugs. Herein, we report the synthesis of Ru, Os, Rh, and Ir half-sandwich complexes with the KSP inhibitor ispinesib and its (

Identifiants

DOI: 10.1039/d3dt01217d PMID: 37464882
pubmed: 37464882
doi: 10.1039/d3dt01217d
doi:

Substances chimiques

Antimitotic Agents 0
ispinesib BKT5F9C2NI
Reactive Oxygen Species 0
Quinazolines 0
Benzamides 0
Antineoplastic Agents 0
Organometallic Compounds 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11859-11874

Auteurs

Michał Łomzik (M)

Department of Organic Chemistry, Faculty of Chemistry, University of Lodz, ul. Tamka 12, 91-403 Łódź, Poland. damian.plazuk@chemia.uni.lodz.pl.
ORCID: 0000-0003-4847-3520

Andrzej Błauż (A)

Cytometry Lab, Department of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Łódź, Poland.
ORCID: 0000-0002-8037-0268

Marta Głodek (M)

Department of Organic Chemistry, Faculty of Chemistry, University of Lodz, ul. Tamka 12, 91-403 Łódź, Poland. damian.plazuk@chemia.uni.lodz.pl.
ORCID: 0000-0002-0528-2364

Anna Makal (A)

Laboratory for Structural and Biochemical Research (LBSBio), Biological and Chemical Research Centre, Department of Chemistry, University of Warsaw, ul. Zwirki i Wigury 101, 02-089 Warszawa, Poland.

Daniel Tchoń (D)

Laboratory for Structural and Biochemical Research (LBSBio), Biological and Chemical Research Centre, Department of Chemistry, University of Warsaw, ul. Zwirki i Wigury 101, 02-089 Warszawa, Poland.
Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
ORCID: 0000-0003-4798-867X

Daniel Moscoh Ayine-Tora (DM)

Department of Chemistry, University of Ghana, LG 56, Legon-Accra, Ghana.

Christian Hartinger (C)

School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
ORCID: 0000-0001-9806-0893

Błażej Rychlik (B)

Cytometry Lab, Department of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Łódź, Poland.
ORCID: 0000-0001-8928-5900

Damian Plażuk (D)

Department of Organic Chemistry, Faculty of Chemistry, University of Lodz, ul. Tamka 12, 91-403 Łódź, Poland. damian.plazuk@chemia.uni.lodz.pl.
ORCID: 0000-0002-2898-6604

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antimitotiques › Organometallic Ru, Os, Rh and Ir half-sandwich...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Organometallic Ru, Os, Rh and Ir half-sandwich...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinazolines › Organometallic Ru, Os, Rh and Ir half-sandwich...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › Organometallic Ru, Os, Rh and Ir half-sandwich...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Organometallic Ru, Os, Rh and Ir half-sandwich...
questionsmedicales.fr › Composés chimiques organiques › Composés organométalliques › Organometallic Ru, Os, Rh and Ir half-sandwich...