Nitric oxide synthase 2 genetic variation rs2297514 associates with a decreased susceptibility to extremity post-traumatic osteomyelitis in a Chinese Han population.
Nos2
case-control study
fracture-related infection
post-traumatic osteomyelitis
rs2297514
single nucleotide polymorphisms
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
03
2023
accepted:
12
06
2023
medline:
21
7
2023
pubmed:
19
7
2023
entrez:
19
7
2023
Statut:
epublish
Résumé
Previous studies have indicated that nitric oxide synthase 2 ( Altogether 704 participants, including 336 PTOM patients and 368 healthy controls, were genotyped of rs2297514 and rs2248814 of the Outcomes showed that the frequency of allele C of rs2297514 in the patient group was significantly lower than that in the control group (48.7% In this Chinese cohort, rs2297514 is correlated with a decreased risk of PTOM development, with genotype CC as a protective factor.
Sections du résumé
Background
Previous studies have indicated that nitric oxide synthase 2 (
Methods
Altogether 704 participants, including 336 PTOM patients and 368 healthy controls, were genotyped of rs2297514 and rs2248814 of the
Results
Outcomes showed that the frequency of allele C of rs2297514 in the patient group was significantly lower than that in the control group (48.7%
Conclusion
In this Chinese cohort, rs2297514 is correlated with a decreased risk of PTOM development, with genotype CC as a protective factor.
Identifiants
pubmed: 37465758
doi: 10.3389/fcimb.2023.1177830
pmc: PMC10350522
doi:
Substances chimiques
Nitric Oxide Synthase Type II
EC 1.14.13.39
NOS2 protein, human
EC 1.14.13.39
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1177830Informations de copyright
Copyright © 2023 Song, Zhang, Lin, Hu, Pan, Jiang and Hu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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