Vimentin: from a cytoskeletal protein to a critical modulator of immune response and a target for infection.
bacterial infections
immune response
intermediate filaments
vimentin
viral infections
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
05
2023
accepted:
20
06
2023
medline:
23
10
2023
pubmed:
21
7
2023
entrez:
21
7
2023
Statut:
epublish
Résumé
Vimentin is an intermediate filament protein that plays a role in cell processes, including cell migration, cell shape and plasticity, or organelle anchorage. However, studies from over the last quarter-century revealed that vimentin can be expressed at the cell surface and even secreted and that its implications in cell physiology largely exceed structural and cytoskeletal functions. Consequently, vimentin contributes to several pathophysiological conditions such as cancer, autoimmune and inflammatory diseases, or infection. In this review, we aimed at covering these various roles and highlighting vimentin implications in the immune response. We also provide an overview of how some microbes including bacteria and viruses have acquired the ability to circumvent vimentin functions in order to interfere with host responses and promote their uptake, persistence, and egress from host cells. Lastly, we discuss the therapeutic approaches associated with vimentin targeting, leading to several beneficial effects such as preventing infection, limiting inflammatory responses, or the progression of cancerous events.
Identifiants
pubmed: 37475865
doi: 10.3389/fimmu.2023.1224352
pmc: PMC10354447
doi:
Substances chimiques
Vimentin
0
Cytoskeletal Proteins
0
Intermediate Filament Proteins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1224352Informations de copyright
Copyright © 2023 Arrindell and Desnues.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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