3,5,7-trihydroxyflavone restricts proliferation of androgen-independent human prostate adenocarcinoma cells by inducing ROS-mediated apoptosis and reduces tumour growth.
3,5,7-trihydroxyflavone
Cell-cycle
EAC
Flavonoids
MMP
PC-3
ROS
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
25
06
2023
received:
27
05
2022
accepted:
08
07
2023
medline:
10
11
2023
pubmed:
21
7
2023
entrez:
21
7
2023
Statut:
ppublish
Résumé
Flavonoids are among the largest groups of secondary metabolites. Studies suggest that dietary intake of flavonoids reduces the risk of cancer. 3,5,7-trihydroxyflavone (THF) belongs to the flavone class of flavonoids and potentially inhibits the growth of many cancers; however, it is unexplored in prostate cancer. This study reports the antiproliferative potential of THF in prostate cancer cell line via reactive oxygen species (ROS)-mediated cascades and examines the tumour reduction potential in swiss albino mice. The potency of THF was evaluated by employing cytotoxicity assays and wound healing assays. Cell cycle, ROS, mitochondrial membrane potential (MMP), and Annexin-V-FITC assay were performed using a flow cytometer. In vivo, anticancer potential was achieved using the mice Ehrlich Ascites Carcinoma (EAC) model. THF inhibits cell growth with IC
Substances chimiques
Reactive Oxygen Species
0
Androgens
0
Fluorescein-5-isothiocyanate
I223NX31W9
Flavonoids
0
Annexins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23474Subventions
Organisme : Central Institute of Medicinal and Aromatic Plants
ID : DU2/MLP 11
Organisme : CSIR-CIMAP
ID : (DU2/MLP-11)
Informations de copyright
© 2023 Wiley Periodicals LLC.
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