Exploring the 1,3-benzoxazine chemotype for cannabinoid receptor 2 as a promising anti-cancer therapeutic.

Humans Benzoxazines / pharmacology Neoplasms / drug therapy Signal Transduction Molecular Dynamics Simulation Receptors, Cannabinoid Receptor, Cannabinoid, CB2 Receptor, Cannabinoid, CB1 Cannabinoid Receptor Agonists
1,3-Benzoxazin-4-one CB(2) Cancer Inflammation Neurodegenerative disorders Neuropathic pain

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
05 Nov 2023
Historique:
received: 10 05 2023
revised: 12 07 2023
accepted: 13 07 2023
medline: 22 8 2023
pubmed: 22 7 2023
entrez: 21 7 2023
Statut: ppublish

Résumé

The discovery of selective agonists of cannabinoid receptor 2 (CB

Identifiants

DOI: 10.1016/j.ejmech.2023.115647 PMID: 37478557
pubmed: 37478557
pii: S0223-5234(23)00613-X
doi: 10.1016/j.ejmech.2023.115647
pii:
doi:

Substances chimiques

Benzoxazines 0
Receptors, Cannabinoid 0
Receptor, Cannabinoid, CB2 0
Receptor, Cannabinoid, CB1 0
Cannabinoid Receptor Agonists 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115647

Informations de copyright

Copyright © 2023 Elsevier Masson SAS. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no competing financial interest.

Auteurs

Nicola Gambacorta (N)

Department of Pharmacy-Pharmaceutical Sciences, University of the Studies of Bari "Aldo Moro", Via E. Orabona 4, 70125, Bari, Italy.

Valeria Gasperi (V)

Department of Experimental Medicine, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy.

Tatiana Guzzo (T)

C4T S.r.l Colosseum Combinatorial Chemistry Centre for Technology, Via Della Ricerca Scientifica Snc, 00133, Rome, Italy.

Francesco Saverio Di Leva (FS)

Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131, Naples, Italy.

Fulvio Ciriaco (F)

Department of Chemistry, University of the Studies of Bari "Aldo Moro", Via E. Orabona 4, 70125, Bari, Italy.

Cristina Sánchez (C)

Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, C/ José Antonio Nováis, 12, 28040, Madrid, Spain.

Valentina Tullio (V)

Department of Experimental Medicine, Tor Vergata University of Rome, Via Montpellier 1, 00133, Rome, Italy.

Diego Rozzi (D)

C4T S.r.l Colosseum Combinatorial Chemistry Centre for Technology, Via Della Ricerca Scientifica Snc, 00133, Rome, Italy.

Luciana Marinelli (L)

Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131, Naples, Italy.

Alessandra Topai (A)

C4T S.r.l Colosseum Combinatorial Chemistry Centre for Technology, Via Della Ricerca Scientifica Snc, 00133, Rome, Italy. Electronic address: alessandra.topai@c4t.it.

Orazio Nicolotti (O)

Department of Pharmacy-Pharmaceutical Sciences, University of the Studies of Bari "Aldo Moro", Via E. Orabona 4, 70125, Bari, Italy. Electronic address: orazio.nicolotti@uniba.it.

Mauro Maccarrone (M)

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, 67100, Coppito, L'Aquila, Italy; European Center for Brain Research/Santa Lucia Foundation IRCCS, Via Del Fosso di Fiorano 64, 00143, Rome, Italy. Electronic address: mauro.maccarrone@univaq.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exploring the 1,3-benzoxazine chemotype for...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzoxazines › Exploring the 1,3-benzoxazine chemotype for...
questionsmedicales.fr › Tumeurs › Exploring the 1,3-benzoxazine chemotype for...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Exploring the 1,3-benzoxazine chemotype for...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Exploring the 1,3-benzoxazine chemotype for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Exploring the 1,3-benzoxazine chemotype for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Récepteur cannabinoïde de type CB2 › Exploring the 1,3-benzoxazine chemotype for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Récepteur cannabinoïde de type CB1 › Exploring the 1,3-benzoxazine chemotype for...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Modulateurs des récepteurs de cannabinoïdes › Agonistes des récepteurs de cannabinoïdes › Exploring the 1,3-benzoxazine chemotype for...