Left ventricular remodeling in rheumatoid arthritis patients without clinical heart failure.
Heart failure
Interleukin-6
Left ventricular remodeling
Rheumatoid arthritis
Journal
Arthritis research & therapy
ISSN: 1478-6362
Titre abrégé: Arthritis Res Ther
Pays: England
ID NLM: 101154438
Informations de publication
Date de publication:
21 07 2023
21 07 2023
Historique:
received:
10
05
2023
accepted:
11
07
2023
medline:
24
7
2023
pubmed:
22
7
2023
entrez:
21
7
2023
Statut:
epublish
Résumé
Rheumatoid arthritis (RA) patients have a 1.5- to twofold higher risk of developing heart failure (HF) and a twofold increased risk of HF-associated mortality compared to those without RA. HF is preceded subclinically by left ventricular (LV) remodeling in the general population. There is a relative absence of prospective studies following RA patients from pre-clinical to clinical HF as well as prospective studies of LV remodeling in RA without clinical HF. In our study, 158 RA patients without clinical HF were enrolled and underwent transthoracic echocardiography (TTE) at baseline and on follow-up between 4 and 6 years. Extensive characterization of RA disease activity and cardiovascular risk factors were performed. LV remodeling was prevalent at 40% at baseline and increased to 60% over time. Higher levels of interleukin-6 (IL 6) were associated with concentric LV remodeling on follow-up. The use of tocilizumab was also significantly associated with baseline LV remodeling (relative wall thickness). These findings suggest a role for IL-6 as a biomarker for LV remodeling in RA patients without clinical HF. Future research should focus on prospective follow-up of LV remodeling and the effects of IL-6 inhibition on LV remodeling in RA patients.
Identifiants
pubmed: 37480064
doi: 10.1186/s13075-023-03113-8
pii: 10.1186/s13075-023-03113-8
pmc: PMC10362590
doi:
Substances chimiques
Interleukin-6
0
Types de publication
Letter
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
124Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR050026
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR068043
Pays : United States
Informations de copyright
© 2023. The Author(s).
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