Metal-Phenolic Nanomedicines Regulate T-Cell Antitumor Function for Sono-Metabolic Cancer Therapy.

Humans Nanomedicine T-Lymphocytes, Regulatory Neoplasms / drug therapy CD8-Positive T-Lymphocytes Glucose / metabolism Tumor Microenvironment
CTLA-4 blockade TME reprogramming Treg cell destabilization mitochondrial dysfunction sono-metabolic therapy

Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
08 08 2023
Historique:
medline: 9 8 2023
pubmed: 24 7 2023
entrez: 24 7 2023
Statut: ppublish

Résumé

Cancer cells outcompete tumor-infiltrating T lymphocytes (TILs) for glucose uptake, manipulating a glucose-deprived tumor microenvironment (TME) with high accumulation of lactate, which impairs CD8

Identifiants

DOI: 10.1021/acsnano.3c02428 PMID: 37486249
pubmed: 37486249
doi: 10.1021/acsnano.3c02428
doi:

Substances chimiques

Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

14667-14677

Auteurs

Jie Yan (J)

Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China.
MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR 999078, China.

Wenxi Li (W)

Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China.
MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR 999078, China.

Hao Tian (H)

Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China.
MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR 999078, China.

Bei Li (B)

Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China.
MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR 999078, China.

Xinying Yu (X)

Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China.
MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR 999078, China.

Guohao Wang (G)

Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China.
MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR 999078, China.

Wei Sang (W)

Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China.
MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR 999078, China.

Yunlu Dai (Y)

Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China.
MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR 999078, China.
ORCID: 0000-0003-4023-7320

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metal-Phenolic Nanomedicines Regulate T-Cell...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Miniaturisation › Nanotechnologie › Nanomédecine › Metal-Phenolic Nanomedicines Regulate T-Cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Metal-Phenolic Nanomedicines Regulate T-Cell...
questionsmedicales.fr › Tumeurs › Metal-Phenolic Nanomedicines Regulate T-Cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Metal-Phenolic Nanomedicines Regulate T-Cell...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Metal-Phenolic Nanomedicines Regulate T-Cell...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Metal-Phenolic Nanomedicines Regulate T-Cell...