The regulation of human organic anion transporter 4 by insulin-like growth factor 1 and protein kinase B signaling.

Pregnancy Female Humans Insulin-Like Growth Factor I / metabolism Proto-Oncogene Proteins c-akt / metabolism Organic Anion Transporters, Sodium-Independent / metabolism Signal Transduction Hormones
Drug transporter Human organic anion transporter 4 IGF-1 Protein kinase B Regulation SUMOylation

Journal

Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032

Informations de publication

Date de publication:
09 2023
Historique:
received: 29 04 2023
revised: 07 07 2023
accepted: 21 07 2023
pmc-release: 01 09 2024
medline: 6 9 2023
pubmed: 25 7 2023
entrez: 24 7 2023
Statut: ppublish

Résumé

Human organic anion transporter 4 (hOAT4), mainly expressed in the kidney and placenta, is essential for the disposition of numerous drugs, toxins, and endogenous substances. Insulin-like growth factor 1 (IGF-1) is a hormone generated in the liver and plays important roles in systemic growth, development, and metabolism. In the current study, we explored the regulatory effects of IGF-1 and downstream signaling on the transport activity, protein expression, and SUMOylation of hOAT4. We showed that IGF-1 significantly increased the transport activity, expression, and maximal transport velocity V

Identifiants

DOI: 10.1016/j.bcp.2023.115702 PMID: 37487877 PMC: PMC10528241
pubmed: 37487877
pii: S0006-2952(23)00293-9
doi: 10.1016/j.bcp.2023.115702
pmc: PMC10528241
mid: NIHMS1921761
pii:
doi:

Substances chimiques

Insulin-Like Growth Factor I 67763-96-6
Proto-Oncogene Proteins c-akt EC 2.7.11.1
Organic Anion Transporters, Sodium-Independent 0
Hormones 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

115702

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM079123
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM097000
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

Zhou Yu (Z)

Department of Pharmaceutics, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.

Haoxun Wang (H)

Department of Pharmaceutics, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.

Guofeng You (G)

Department of Pharmaceutics, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA. Electronic address: gyou@pharmacy.rutgers.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › The regulation of human organic anion...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The regulation of human organic anion...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Somatomédines › Facteur de croissance IGF-I › The regulation of human organic anion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › The regulation of human organic anion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques sodium-indépendants › The regulation of human organic anion...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The regulation of human organic anion...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › The regulation of human organic anion...