Keratin 7 expression in different anatomical parts of colonic epithelium in inflammatory bowel diseases and its prognostic value: a 3-year follow-up study.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 07 2023
24 07 2023
Historique:
received:
04
05
2023
accepted:
19
07
2023
medline:
26
7
2023
pubmed:
25
7
2023
entrez:
24
7
2023
Statut:
epublish
Résumé
The diagnosis of inflammatory bowel diseases (IBD) may be challenging and their clinical course, characterized by relapses and spontaneous or drug-induced remissions, is difficult to predict. Novel prognostic biomarkers are needed. Keratin 7 (K7) is a cytoskeletal intermediate filament protein which is not normally expressed in the colonic epithelium. It was recently shown that K7 expression in the colonic epithelium is associated with ulcerative colitis and Crohn's disease, the two main subtypes of IBD. Here we investigated IBD associated K7 neo-expression in different regions of colon and terminal ileum. The correlation of the K7 expression with the inflammatory activity of the epithelium was analyzed in each region. The prognostic value of K7 was estimated by comparing the clinical disease activity after 3 years with the K7 expression at the time of enrollment. Our data shows that the level of K7 expression in inflamed epithelium varies depending on the anatomical region and it is the most pronounced in ascending and descending colon, but it did not predict the severity of IBD for the following 3 years. These results warrant future studies focusing on the biological role of K7 in colon and its utilization as potential IBD biomarker.
Identifiants
pubmed: 37488244
doi: 10.1038/s41598-023-39066-w
pii: 10.1038/s41598-023-39066-w
pmc: PMC10366087
doi:
Substances chimiques
Keratin-7
0
Intermediate Filament Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11979Informations de copyright
© 2023. The Author(s).
Références
J Pathol. 1991 Oct;165(2):145-52
pubmed: 1720817
Neurogastroenterol Motil. 2018 Jan;30(1):
pubmed: 28975689
Gastroenterology. 1976 Mar;70(3):439-44
pubmed: 1248701
Clin Cancer Res. 1999 Oct;5(10):2840-7
pubmed: 10537351
Aliment Pharmacol Ther. 2003 Jun;17 Suppl 2:11-7
pubmed: 12786607
Int J Biochem Cell Biol. 2020 Dec;129:105878
pubmed: 33152513
Curr Opin Cell Biol. 2002 Feb;14(1):110-22
pubmed: 11792552
APMIS. 2007 Nov;115(11):1219-26
pubmed: 18092953
Genes Genomics. 2021 Dec;43(12):1389-1402
pubmed: 34562265
Cell Mol Life Sci. 2021 Dec 24;79(1):10
pubmed: 34951664
Sci Rep. 2022 Dec 23;12(1):22213
pubmed: 36564440
J Mol Biol. 1984 Sep 15;178(2):365-88
pubmed: 6208369
Virchows Arch. 2006 Jun;448(6):756-62
pubmed: 16609910
Am J Pathol. 1990 Mar;136(3):641-55
pubmed: 1690512
Gut. 1998 Jul;43(1):29-32
pubmed: 9771402
Mol Cell Proteomics. 2014 Sep;13(9):2277-87
pubmed: 24889196
Nat Rev Gastroenterol Hepatol. 2016 Jan;13(1):13-27
pubmed: 26627550
Ann Palliat Med. 2021 Sep;10(9):9544-9552
pubmed: 34628880
J Gastroenterol Hepatol. 2022 Mar;37(3):440-445
pubmed: 34750862
Int J Exp Pathol. 2012 Oct;93(5):305-18
pubmed: 22974212
Hepatol Res. 2023 Apr;53(4):322-333
pubmed: 36495019
BMJ Open Gastroenterol. 2015 May 18;2(1):e000024
pubmed: 26462276
J Gastroenterol. 2021 Jun;56(6):489-526
pubmed: 33885977
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
Virchows Arch. 2021 Oct;479(4):815-824
pubmed: 34312700
Nature. 2019 Mar;567(7746):49-55
pubmed: 30814735
Ann Diagn Pathol. 2016 Feb;20:36-9
pubmed: 26670478
Int J Mol Sci. 2021 May 18;22(10):
pubmed: 34070214
Int J Mol Sci. 2023 Mar 15;24(6):
pubmed: 36982676
J Physiol. 2002 Mar 1;539(Pt 2):361-71
pubmed: 11882670
J Clin Invest. 2009 Jul;119(7):1794-805
pubmed: 19587454
Cancers (Basel). 2022 Mar 23;14(7):
pubmed: 35406395
Biomedicines. 2022 Jun 24;10(7):
pubmed: 35884797
J Crohns Colitis. 2022 Jan 28;16(1):162-165
pubmed: 34240137
Acta Radiol. 2021 Jul;62(7):851-857
pubmed: 32722966
Gut. 1998 Aug;43(2):294-9
pubmed: 10189861
Cell. 1982 Nov;31(1):11-24
pubmed: 6186379
J Crohns Colitis. 2013 Nov;7(10):827-51
pubmed: 23870728
Subcell Biochem. 2017;82:171-230
pubmed: 28101863
Am J Physiol Gastrointest Liver Physiol. 2011 Jan;300(1):G82-98
pubmed: 21030607
Gastroenterology. 1994 Jul;107(1):3-11
pubmed: 8020674
Lancet. 2018 Dec 23;390(10114):2769-2778
pubmed: 29050646