Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
28 07 2023
28 07 2023
Historique:
medline:
28
7
2023
pubmed:
26
7
2023
entrez:
26
7
2023
Statut:
ppublish
Résumé
Lysosome dysfunction arises early and propels Alzheimer's disease (AD). Herein, we show that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts directly via its β-C-terminal fragment (βCTF) to disrupt lysosomal vacuolar (H
Identifiants
pubmed: 37494443
doi: 10.1126/sciadv.adg1925
pmc: PMC10371027
doi:
Substances chimiques
Amyloid beta-Protein Precursor
0
Adenosine Triphosphatases
EC 3.6.1.-
Amyloid beta-Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eadg1925Subventions
Organisme : NIA NIH HHS
ID : P01 AG017617
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062376
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR027990
Pays : United States
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