Cysteines 1078 and 2991 cross-linking plays a critical role in redox regulation of cardiac ryanodine receptor (RyR).


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
26 07 2023
Historique:
received: 07 11 2022
accepted: 19 07 2023
medline: 28 7 2023
pubmed: 27 7 2023
entrez: 26 7 2023
Statut: epublish

Résumé

The most common cardiac pathologies, such as myocardial infarction and heart failure, are associated with oxidative stress. Oxidation of the cardiac ryanodine receptor (RyR2) Ca

Identifiants

pubmed: 37495581
doi: 10.1038/s41467-023-40268-z
pii: 10.1038/s41467-023-40268-z
pmc: PMC10372021
doi:

Substances chimiques

Calcium SY7Q814VUP
Disulfides 0
Ryanodine Receptor Calcium Release Channel 0
RyR2 protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

4498

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL151990
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Roman Nikolaienko (R)

Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, 60153, USA.

Elisa Bovo (E)

Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, 60153, USA.

Daniel Kahn (D)

Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, 60153, USA.

Ryan Gracia (R)

Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, 60153, USA.

Thomas Jamrozik (T)

Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, 60153, USA.

Aleksey V Zima (AV)

Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, 60153, USA. azima@luc.edu.

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Classifications MeSH